PubMed Health⌕ Search

Biomedical subjects

R Miyazaki

Publications and source records attributed to R Miyazaki.

88 records · Page 5Linked to original sources
PubMed1982

[Clinical experience of netilmicin on chronic urinary tract infections (author's transl)].

Daily 150 mg or 200 mg dose of netilmicin (NTL) were administered to 26 patients with chronic complicated urinary tract infections for 5 days, and the following results were obtained. 1) Out of 26 cases excellent response was seen in 5 cases, good response in 4, and poor response in 11. Effectiveness rate was 45%. Six cases were excluded from the evaluation. 2) Effective result was not seen in the catheterized group, whereas 5 excellent and 4 good cases were observed in the noncatheterized group, resulting 60% in effectiveness rate. 3) MICs of NTL against various bacteria were comparative to GM against P. aeruginosa, to AMK against Serratia, and to both GM and AMK against other bacteria. 4) Except a slight local irritation, no subjective side effect was observed. One case showed a slight elevation in hepatic function tests but it was not definitely judged as the side effect due to NTL.

Adult↗
PubMed1981

Successful treatment of fulminating complications associated with extensive rhabdomyolysis by plasma exchange.

The first successful treatment by plasma exchange of acute renal failure and disseminated intravascular coagulation, as well as liver and central nervous system damage, was achieved in two patients with severe multiorgan damage associated with extensive muscle tissue damage caused by heatstroke and/or electrical injury. Substances derived from damaged muscle tissue, such as myoglobin and enzymes, were efficiently removed by a cellulose acetate membrane filter. Improvement of consciousness, disturbance, coagulation disorder, and renal failure were observed. The disorders associated with extensive rhabdomyolysis seem to be a promising indication for this therapy. Plasma exchange with a membrane filter is useful for treatment of patients with renal failure, being readily connected on-line with conventional dialysis.

Acute Kidney Injury↗
PubMedDate not supplied

Plasminogen with type-I mutation is polymorphic in the Japanese population.

A functionally inactive plasminogen (PLG) variant designated as PLG M5 is polymorphic in the Japanese population and has a feature common to PLG with type-I mutation that has a codon 601 missense mutation in exon 15 (GCT for Ala-->ACT for Thr). This study was conducted to clarify whether the type-I mutation of PLG is present in PLG M5 and polymorphic in the Japanese population. Direct sequencing of the amplified DNA from the PLG gene in a heterozygote for PLG M5 revealed that the sequence of the exon 15 in the gene for PLG M5 is identical with that in the PLG gene with type-I mutation. In addition, the amplified DNA from the PLG gene in 12 heterozygotes for PLG M5 reacted with the probe for the type-I mutation in dot blot hybridization with an allele-specific oligonucleotide probe. The heterozygote for PLG with type-I mutation was found in 2.2% of 360 unrelated healthy subjects. These data indicate that the type-I mutation of PLG is present in PLG M5 and polymorphic in the Japanese population. The data also suggest that the PLG M5 is identical with PLG Tochigi and Kagoshima.

Asian People↗
PubMedDate not supplied

Segmental pancreatectomy for the diagnosis and treatment of small lesions in the neck or body of the pancreas.

BACKGROUND/AIMS: To avoid any profound deficit in the pancreatic functions as well as to successfully make a histological diagnosis of such lesions, we performed resections of a small segment of the pancreatic neck or body. This article discusses the practicality of this procedure as well as the complications and evaluation of the pancreatic functions after surgery. PATIENTS AND METHODS: A segmental pancreatectomy was performed in patients with small lesions of the pancreatic neck or body. There were a total of 24 patients including 11 with hyperplasia, 7 with chronic pancreatitis, 4 with mucinous or serous cystadenoma, and each one with islet cell carcinoma (low-grade malignancy) and carcinoma in situ. RESULTS: No major complications occurred following surgery. The pancreatic endocrine and exocrine functions were well maintained in all patients except for two with chronic pancreatitis. CONCLUSIONS: Based on our findings, a segmental pancreatectomy for small lesions in the pancreatic neck or body seems to be a safe and effective procedure for minimizing the postoperative deficit in the pancreatic functions, while it also allows for an accurate diagnosis of lesions that are often difficult to differentially diagnose for malignancy.

Adult↗