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R Moller

Publications and source records attributed to R Moller.

6 recordsLinked to original sources
PubMed1978

[Bilirubin UDP-glucuronyltransferase activity in human fetal liver homogenates].

The bilirubin UDP GT-activity of the liver was studied from week 15 of pregnancy in 23 human fetuses and mature and immature dead newborns, respectively. No measurable bilirubin UDP GT-activity was found up to week 26 of pregnancy. The development of enzymatic activity presumably starts only postnatally, irrespective of gestational age of birth weight. Up to the fifth day the bilirubin UDP GT-activity is less than 0.2 mg of conjugated bilirubin/g liver/h, reaching in the second week values that correspond to approximately 20--30% of adult values. This activity is sufficient to prevent a clinically important hyperbilirubinemia because the concentration of unconjugated serum bilirubin was in all children below 12mg/100 ml.

Bilirubin↗
PubMed1978

Relationship between arsenic intake and internal malignant neoplasms.

An attempt has been made to assess the carcinogenic effect of arsenic intake by analyzing a group of patients who were treated with arsenic for various skin diseases in the 1930s. When compared with the expected incidence of malignant internal neoplasms, based on figures obtained from the Danish Cancer Registry, a significant increase in the incidence of internal malignant neoplasms was observed in females with multiple basal cell carcinomas. A group comprising 53 patients with arsenic keratoses presented a considerable increase in the incidence of internal malignant neoplasms. However, these patients were so specifically selected that no regular statistical analysis can be made of this group. It may be said that arsenic has a carcinogenic effect even in the relatively small doses applied in dermatological therapy.

Aged↗
PubMed1976

Gentamicin-induced nephropathy.

162 consecutive gentamicin courses have been evaluated retrospectively with respect to nephrotoxicity of gentamicin (GM). Of these, 120 courses were administered in 106 patients for more than 2 days and under adequate control of plasma creatinine (PCr). In 62 of these 120 courses, PCr concentrations increased. In 17 courses (14%), GM therapy was found to be the only demonstrable etiology to the rise in PCr. The 17 courses with GM-induced reduction in kidney function were characterized by a prolonged duration of treatment, a high total dose of GM and a somewhat higher level of serum GM than the 58 courses of GM treatment in which PCr remained unchanged. No significant differences were found with regard to age, average daily dose of GM, average daily dose per kg and average daily dose in proportion to average diuresis. Additional administration of other nephrotoxic drugs did not increase the incidence of GM-induced nephropathy. When GM was the only demonstrable cause of nephropathy, the elevation in PCr concentrations were generally mild and transient, while the nephropathy when other factors were involved more often became severe and occasionally irreversible.

Adolescent↗
PubMed1975

[Separation of reb blood cells in the isopyknic dextran and albumin density gradient].

The separation of red blood cells according to their maturity and age was compared in the isopyknic dextran and albumin density gradients, and the quality of separation was appraised by selected criteria (density distribution curves, accumulation of reticulocytes, activity of G-6-PD). The achieved quality of separation, as measured by the quotient of G-6-PD activity in the cells of lower density/G-6-PD activity in cells of higher density is of equal value in the two media. In the dextran gradient, separation of old cells seems to be accomplished more readily, while albumin affords better separation of young erythrocytes. The reticulocytes are in both media 4-5 mg/ml lighter than the total cell population. When shifting pH from 7.4 to 6.8 both in erythrocytes and reticulocytes the density decreases by 3-6 mg/ml irrespective of the type and pretreatment of the separation medium.

Albumins↗