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Biomedical subjects

R Moses

Publications and source records attributed to R Moses.

At least 19 recordsLinked to original sources
PubMed1995

Is there a seasonal variation in the incidence of gestational diabetes?

It has been suggested that the incidence of gestational diabetes (GDM) may vary with different seasons of the year. The fasting and 2 h glucose levels after a 75 g glucose tolerance test were therefore examined in 2749 women being tested for GDM and were correlated with the mean temperature at 0900 h by month and by season. The mean monthly temperature ranged from 22.3 degrees C in January to 13.6 degrees C in July. The monthly incidence of GDM ranged from 3.5% (95% CI, 0.7-6.3) in September to 8.7% (4.7-12.7) in November. The seasonal incidence of GDM ranged from 7.4% (5.6-9.2) in autumn to 5.5% (3.5-7.5) in winter. Chi-squared analysis did not suggest a significant association between the proportion of women diagnosed with GDM and either the month (p = 0.47) or the season (p = 0.39). Multiple regression analysis, after correction for maternal age, parity, BMI, and the week of testing revealed a non-significant association between fasting glucose and monthly temperature (p = 0.36) and an increase in the 2 h glucose of 0.026 mmol l-1 for each increase of 1 degree C in temperature (p = 0.011). In a temperate coastal area of Australia these differences do not appear clinically significant and have not caused a variation in the incidence of GDM with different seasons.

Adult↗
PubMed1995

Diabetic control and hypoglycaemia in the Illawarra area of NSW, Australia: a comparison with the DCCT.

The level of diabetic control and the number of hypoglycaemic episodes in the intensively treated insulin-dependent diabetes mellitus (IDDM) patients of the Diabetes Control and Complication Trial (DCCT) are a stimulus for other centres to critically examine their results. We examined diabetic control and the number of hypoglycaemic episodes in an unselected group of patients with IDDM diabetes from a population based diabetes register in the Illawarra area of Australia. Eligible patients were insulin dependent, aged 13-39 years, diagnosed for more than 1 year and had had a HbA1c test in the previous 6 months. Better diabetic control was achieved in patients with IDDM, without the need for intensive insulin therapy, than the intensively treated patients of the DCCT with fewer hypoglycaemic events. Before intensive insulin therapy for all patients with IDDM is considered, different models of diabetic healthcare delivery and medical treatment philosophies need to be examined.

Adolescent↗
PubMed1992

Health service utilisation in the public and private sector by patients with diabetes mellitus aged less than 40 years.

This paper uses the Illawarra 0-39 years diabetes register to provide a data base of health service utilisation in the public and private sectors. Eligible patients from the register were divided into a 'stable group' comprising children and adults who had had diabetes for more than one year prior to review and a 'newly diagnosed' group who were followed for one year after diagnosis. The records of inpatient and selected outpatient services at public hospitals as well as visits to general practitioners, paediatricians and physicians were considered. Less than half of all 'newly diagnosed' patients were admitted to hospital for stabilisation and none required readmission in the 12 month review period. Less than one fifth of all 'stable' patients were admitted to hospital during the year. General practitioners were the most frequently used health resource being attended by 31/38 (82%) 'stable children', 122/133 (92%) 'stable adults' and 25/25 (100%) 'newly diagnosed patients'. Public hospital Accident and Emergency Services were the least used health facility being frequented by only 9/38 (24%), 23/133 (17%) and 7/25 (28%) respectively.

Adolescent↗
PubMed1991

A quality assurance audit of Illawarra PADP Scheme home glucose meters and evaluation of their use by patients.

A total of 187 home glucose meters have been issued to Illawarra residents by the Program of Aids for Disabled Patients (PADP) Scheme operating out of Port Kembla District Hospital in a 5-year period ending 31 December 1989. These meters, representing a valuable health resource, have been loaned to patients without audit or follow up. Sixteen per cent of meters were unable to be located and 33.2% could not be located using existing PADP records. Of those meters which could be tested, 16.4% were inaccurate; the recipient's technique was inadequate for accurate results in 36.1% of instances. This survey has revealed a significant loss of health resources in addition to inadequate clinical assessment and supervision.

Adolescent↗
PubMed1990

Reflections on the sense of entitlement.

This paper looks at entitlement as consisting of three possible modes: an appropriate adequate sense of entitlement; an excessive sense of entitlement; and a sense of entitlement which is not usually in awareness. The authors discuss some of the antecedents of an excessive sense of entitlement as well as certain specific family constellations and traumatic events which seem to encourage or facilitate its existence. Clinical examples are presented to show the importance of an excessive sense of entitlement--related to narcissism--as it appears in psychotherapy or psychoanalysis; yet it is also visible culturally and politically. Entitlement and narcissistic proclivities are viewed according to the developmental history as well as the clinical manifestations (intensity, frequency, duration, and spread).

Adult↗
PubMed1990

Xenograft rejection of class I-expressing transgenic skin is CD4-dependent and CD8-independent.

B10.PD1 mice are transgenic animals expressing a class I MHC antigen of pigs. B10.PD1 skin graft survival on B6 mice was prolonged by anti-CD4 antibody treatment in vivo but not by anti-CD8 treatment. These results suggest: (1) that the defect in cell-mediated recognition of xenografts involves an interaction with the xeno-MHC antigens themselves and not with the cells which express them; (2) that antigen processing and presentation of xeno-antigens on responder-type APCs is required in vivo; and (3) that CD8-independent, possibly noncytotoxic, mechanisms of xenograft rejection may exist.

Animals↗
PubMed1985

Lack of correlation between differentiation status and response to radiation of three murine squamous cell carcinomas.

The gross growth rate, histology, cellular kinetics, and in situ radiobiological response have been measured for three murine, keratinising squamous cell carcinomas that differed in their degree of differentiation. Growth rate was fastest in the least-differentiated tumour, slowest in the best-differentiated. However, the kinetics of the compartment of undifferentiated cells that are likely to be radiotherapeutically important, were the same for the three lines. There was no correlation between degree of differentiation and intrinsic or apparent radiosensitivity as measured by the growth delay assay. The radiobiologically best-oxygenated tumour was that which has the largest stromal component and this was not the best-differentiated tumour.

Animals↗