Pharmacologic intervention in ischemia-induced reperfusion injury in the skeletal muscle.
This article provides a concise review on the potential causes of ischemia-induced reperfusion (I/R) injury and pharmacologic intervention in the skeletal muscle. Special emphasis is placed on the recent observation of the acute ischemic preconditioning phenomenon for prevention of I/R injury in skeletal muscle. Finally, the mechanism of ischemic preconditioning and its clinical applications for augmentation of skeletal muscle tolerance to prolonged ischemic insult are discussed.
Animals↗