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Biomedical subjects

R Muller

Publications and source records attributed to R Muller.

14 recordsLinked to original sources
PubMed1992

Intraductal carcinoma of major salivary gland.

The clinicopathologic features of the cases of three patients with intraductal carcinoma of major salivary gland are described. As in the breast, these lesions of salivary ducts appear to represent an in situ or preinvasive phase of the disease. On follow-up, one patient had a local recurrence, and in another patient, the tumor subsequently became invasive. This experience suggests that wide surgical excision (preferably total parotidectomy) may be curative but that resections limited to grossly visible disease will result in local recurrence and/or the development of invasive ductal adenocarcinoma.

Adenocarcinoma↗
PubMed1992

[Ambulatory phlebectomy].

Ambulatory phlebectomy has been done already in Greek and Roman times. It was since forgotten for many centuries, but it has been revived by Müller in 1956. Ambulatory phlebectomy is one of the most rewarding instances of ambulatory surgery. It consists of the comprehensive extraction of the varices through extremely small stab incisions, followed immediately by vigorous marching. It calls for team work: The surgeon performs the high ligation and stripping of the proximal third of the greater saphenous vein, and the phlebologist removes all the other varices. And it is an almost ideal treatment, as it provides efficiency as well as excellent cosmetic results at low costs and is also harmless.

Ambulatory Surgical Procedures↗
PubMed1979

Guinea worm disease: epidemiology, control, and treatment.

Guinea worm infection is one of the most easily prevented parasitic diseases, but it is nevertheless a common cause of disability in rural areas of Africa, south-west Asia, and India. Infection occurs when drinking water is infested with infected Cyclops, a microcrustacean. Worms up to 70-80 cm in length develop in the subcutaneous tissues of the feet or legs and larvae are liberated to renew the cycle when an infected individual steps into a well or pond from which others draw drinking water. Infection is markedly seasonal because of (a) the influence of the climate on the types of water source used and (b) the developmental cycle of the parasite. The disability may be economically very important if the period of infection coincides with busy periods in the agricultural year. Sieving water through a cloth is sufficient to remove the Cyclops, but on a public health scale improved water supplies are required for control. Once the cycle of reinfection can be broken in any district the disease disappears. Chemical treatment of water bodies with temephos is also an effective and safe way of controlling transmission. Treatment consists of rolling out each emerging worm onto a small stick, a few centimetres each day, and certain drugs reduce the pain and pruritus and enable the worm to be removed more quickly.

Africa↗
PubMed1975

Stimulation of intestinal smooth muscle by atropine, procaine, and tetrodotoxin.

In order to determine whether or not atropine, procaine, and tetrodotoxin (TTX) can stimulate intestinal smooth muscle directly, we examined the effects of these drugs on the mechanical and electrical activities of several types of cat intestinal smooth muscle preparations. The preparations consisted of isolated rings of 1) intact intestinal wall, 2) intact longitudinal and circular muscle, 3) ganglion-free circular muscle, and 4) ganglion-free circular muscle devoid of its dense layer and plexus muscularis profundus. Atropine and procaine (greater than 10(-4) M) stimulated all four types of preparation. On the other hand, TTX (up to 5 X 10(-6) M) stimulated only preparations 1 and 2. It is concluded that whereas atropine and procaine can directly stimulate intestinal smooth muscle, the excitatory effect of TTX is neurally mediated.

Acetylcholine↗
PubMedDate not supplied

[Ambulatory phlebectomy].

Being disappointed in the failures of sclerotherapy in varicose veins, the author resorted to ambulatory phlebectomy. Through very tiny incisions (0.5 to 1 mm) the varicose veins are prepared and completely removed. The arch and the proximal part of the internal saphenous vein are left to the surgeon. This technique described 2,000 years ago by Celsus is easy, effective and innocuous, leaves no marks (no stiches or ligatures) and is also inexpensive because of asepsis, antisepsis and anesthesia. A critical review of 1000 of our cases discloses 70 per cent excellent results. The 30 per cent of accidents were benign and transitory. This technique is almost ideal : A harmless cure that improves the appearance of all type of patients with varicose vein.

Ambulatory Care↗