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Biomedical subjects

R N Hensinger

Publications and source records attributed to R N Hensinger.

At least 127 records · Page 7Linked to original sources
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E-mail medicine.

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Computer Communication Networks↗
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Mouse model for thoracic congenital scoliosis.

SUMMARY: This study sought to produce a dose-response curve for acute and chronic maternal carbon monoxide (CO) exposure versus vertebral anomalies in mouse offspring and to determine the critical day of exposure. In Part I, pregnant CD-1 mice were exposed to an acute dose of CO at 9 days of gestation. A positive dose-response relationship of acute maternal CO exposure and vertebral anomalies in the offspring was produced. In Part II, pregnant females were exposed to chronic CO for the first 11 days of gestation. Chronic exposure to CO did not produce significant vertebral anomalies. In Part III, pregnant females were exposed to an acute dose of 600 ppm of CO at gestation day 8, 9, or 10. Day 9 in this mouse breed is the critical day for maternal exposure to CO. The detected anomalies were predominately in the thoracic spine.

Acute Disease↗
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Intraoperative excision of metal prominences: a technical note.

In situ modification of metal rods can be difficult. High-speed cutting discs are effective in cutting metal prominences which cause soft tissue irritation and bony erosion. Water-soluble jelly can effectively trap the metal debris generated during this cutting process.

Equipment Design↗
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Thick lips, bumpy tongue, and slipped capital femoral epiphysis--a deadly combination.

Multiple endocrine neoplasia type 2b (MEN 2b) is a rare genetic disorder. Affected individuals have malignant thyroid tumors, pheochromocytoma, and ganglioneuromatosis. The musculoskeletal manifestations of MEN 2b include a Marfanoid habitus, pes cavus, scoliosis, slipped capital femoral epiphysis, joint laxity, poor muscle development, and delayed maturation. The initial clinical presentation of MEN 2b frequently involves the musculoskeletal system. The characteristics ganglioneuromatosis of the lips and tongue, however, should alert the orthopedic surgeon to the underlying disorder. Effective treatment of the malignant neoplasms hinges on early diagnosis. The risk of perioperative hypertensive crisis is significant; it may be prevented by appropriate treatment of the pheochromocytoma.

Adolescent↗
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Late effects of JRA on the hip.

Osseous changes at the hips were seen in the radiographs of 36 children with long-standing juvenile rheumatoid arthritis (JRA) and no significant steroid therapy. Seven boys and one girl had progressive primary inflammatory destruction of the hip with erosive arthritis and progressive joint space narrowing. Twenty-one girls and seven boys revealed adaptive developmental changes in the growing skeleton without erosion. Both courses resulted in secondary osteoarthritis and functional disability. Early recognition of adaptive, developmental changes may identify a group of children who may benefit from orthopedic intervention to maintain concentric, congruent reduction at the hip.

Adolescent↗
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Osteonecrosis of the femoral head in a family with hyperlipoproteinemia.

A family of four generations has been identified as having hyperlipoproteinemia as well as radiologic evidence of active or healed osteonecrosis of the femoral head. Sixteen family members were available for complete clinical, radiologic, and laboratory examination. Six living and two deceased members were found to have both conditions. Hyperlipoproteinemia should be considered in the differential diagnosis of the idiopathic osteonecrosis of the femoral head; some common pathogenetic factor may underlie these two conditions when they coexist in a familial pattern.

Adolescent↗
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Behavioral characteristics of children with Legg-Calvé-Perthes disease.

We explored the behavioral characteristics of 24 children with Perthes' disease. Parents completed standard psychological self-administered questionnaires regarding their child's behavior: the Conners Parent Symptom Questionnaire and the Achenbach Child Behavior Checklist. One third (33%) of the children had abnormally high scores in profiles associated with attention deficit hyperactivity disorder (ADHD) (impulsive, hyperactive, and psychosomatic categories), much higher than the 3-5% incidence of ADHD in the general population. They also tended to have difficulties with school and social interaction skills. Certain epidemiologic characteristics of Perthes' disease (sex ratio, socioeconomic status, geographic location, and associated congenital anomalies) are also similar to those of ADHD, suggesting a correlation between the two disorders.

Child↗
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Metastatic vertebral disease in children.

We retrospectively reviewed 19 children with osseous vertebral metastases. The average age was 10.9 years at diagnosis of the primary tumor and 11.2 years at diagnosis of metastasis. The location of the multiple metastases was cervical (three), thoracic (14), and lumbar (10). Treatment consisted of chemotherapy (19), radiation therapy (12), and operation (seven). Ten children died at an average of 13 months after diagnosis of the primary tumor; nine are alive at an average of 72 months after diagnosis. All four children treated with chemotherapy, spinal radiation, and laminectomy, and who survived > 2 months, developed deformity. In this particular situation, we encourage consideration of spinal stabilization when it is appropriately coordinated with radiation and chemotherapy.

Adolescent↗
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Telescoping intramedullary rodding with Bailey-Dubow nails for recurrent pathologic fractures in children without osteogenesis imperfecta.

We reviewed four children with multiple, recurrent, pathologic fractures caused by bone disease, excluding osteogenesis imperfecta, and in whom multiple osteotomies with telescoping intramedullary stabilization had been performed. The diagnoses were myelomeningocele in two children and Rett syndrome and fibrous dysplasia in one child each. Five long bones were stabilized; four femora and one tibia. The average age at surgery was 6 years 6 months; the average number of fractures that had occurred in the involved bone before surgery was 3.0 per bone. At an average follow-up of 2 years 4 months, the average number of fractures that had occurred after surgery in the stabilized bones was 0.2 per bone. There were no infections, nonunions, or rod complications. We believe that in the carefully selected patient, multiple osteotomies with intramedullary telescoping rod stabilization can be quite successful in solving the problem of recurrent fractures in children with diseases other than osteogenesis imperfecta.

Bone Nails↗
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Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot.

Clubfoot is a birth defect that may be related to muscle weakness or imbalance. The purpose of this study was to examine the relationships among muscle and tendon size and embryonic motility in a paralyzed chick embryo model of clubfoot and arthrogryposis. Decamethonium bromide, a neuromuscular blocking agent, was administered to a series of embryos in five dosage groups, producing a cohort of embryos with various degrees of paralysis and atrophy of tendons and muscle. Embryonic movement frequency was monitored, and after death in late gestation, the cross-sectional areas of the calf musculature and the gastrocnemius tendon proximal to the ankle were measured histologically. Significant correlations were found between embryonic motility and both muscle (r2 = 0.52) and tendon (r2 = 0.77) areas. In addition, a significant correlation (r2 = 0.74) was found between muscle and tendon areas, suggesting that a measurement of one may be used to predict the other.

Animals↗