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Biomedical subjects

R N MacSween

Publications and source records attributed to R N MacSween.

At least 127 records · Page 7Linked to original sources
PubMed1973

Hepatic cirrhosis: a clinico-pathological review of 520 cases.

A clinico-pathological review of 520 patients with hepatic cirrhosis coming to necropsy at the Western Infirmary, Glasgow over the period 1900-69 is reported. There has been an overall increase in incidence of cirrhosis since the 1940s, and this has been largely due to a rise in female incidence. A similar trend in the period 1940-71 has been confirmed at a national level in data abstracted from the Annual Reports of the Registrar General for Scotland. The mean age at death has risen for both sexes. Aetiologically, the cirrhosis was alcoholic in 18.5%, posticteric in 10.4%, cryptogenic in 61.9%, and haemochromatosis was diagnosed in 7.5%. Primary malignant tumours of liver supervened in 12.3%. The causes of death and the morphological patterns of the cirrhosis are reviewed.

Adolescent↗
PubMed1973

Australia antigen and primary biliary cirrhosis.

Sera from 64 patients with primary biliary cirrhosis have been examined for Australia antigen (Au). On immunodiffusion and immunoelectrophoresis all sera were negative. Using a radioimmunoprecipitation technique 15.6% of sera contained antigen compared with an incidence of 3.1% in matched controls, a significant difference (p = 0.015). Anti-Au was found in 9.4% of patients and in 7.8% of controls. In lymphocyte transformation studies lymphocytes from one of 24 patients with primary biliary cirrhosis transformed on stimulation with an Au-rich serum.

Antibodies, Viral↗
PubMed1973

Mallory's ('alcoholic') hyaline in primary biliary cirrhosis.

Mallory's (;alcoholic') hyaline has been found in hepatocytes in 18 of 70 patients with primary biliary cirrhosis. These inclusions have previously been noted in only three cases of primary biliary cirrhosis. Current views on the nature of Mallory's hyaline are briefly discussed.

Alcoholism↗
PubMed1972

Serum protein levels in primary biliary cirrhosis.

Serum levels of albumin, transferrin, alpha(2)-macroglobulin, beta(1)C/beta(1)A, IgA, IgG, and IgM have been determined in 73 patients with primary biliary cirrhosis and in age- and sex-matched controls. A highly significant fall in albumin was demonstrated, and there were highly significant increases in alpha(2)-macroglobulin and all three immunoglobulin levels. Transferrin and beta(1)/Cbeta(1)A levels were unchanged. No significant correlations were found between the titre of antimitochondrial antibody, the duration of symptoms, and any of the serum proteins estimated. A highly significant positive correlation was present between serum albumin and transferrin levels in both patient and control groups.

Adult↗