[Elevated gamma-glutamyltransferase].
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Alcoholism↗
Biomedical subjects
R N Schöngen
Publications and source records attributed to R N Schöngen.
[Critical evaluation of fibronectin in pregnancy-induced hypertension/pre-eclampsia and placental insufficiency].
1. Fibronectin does not correlate with the grade of proteinuria. 2. Fibronectin does not correlate with birth weight. 3. Fibronectin level is not elevated in pregnancy-induced hypertension and preeclampsia. 4. Fibronectin level is elevated in cases of preeclampsia, combined with chronic placental insufficiency respectively intrauterine growth retardation. 5. There is a statistic significant difference between pregnancy-induced hypertension/preeclampsia with or with out placental insufficiency. 6. Extremely problematic pregnancies ended in all pregnancies with values of fibronectin above 0.4 g/l in caesarean section without knowledge of the elevated fibronectin level at the time of operation. 7. In the group of pregnancy-induced hypertension the fibronectin level is elevated in relation to control group. This increase is particularly evident, if a placental insufficiency is concontinant with preeclampsia.
Adult↗
Effect of diacetylrhein on the phagocytosis of polymorphonuclear leucocytes and its influence on the biosynthesis of hyaluronate in synovial cells.
1. The influence of diacetylrhein on the luminol-induced chemiluminescence of zymosan-activated polymorphonuclear leucocytes (PMNL) was investigated. At a concentration of 4 x 10(-5) mol/l diacetylrhein an inhibition of about 40% was found. 2. A model for the degradation of hyaline cartilage by frustrated phagocytosis was developed, in which human polymorphonuclear leucocytes cause a release of glycosaminoglycan peptides from hyaline cartilage slices (bovine nasal septum). We observed a 20% inhibition of this release at a concentration of 10(-4) mol/l diacetylrhein. 3. Human synovial fibroblasts synthesize the glycosaminoglycan hyaluronate. As a parameter of the rate of hyaluronate synthesis we measured the incorporation of 14C-glucosamine into hyaluronate. At a concentration of 2 x 10(-4) mol/l diacetylrhein a 4-fold increase of 14C-glucosamine incorporation in the membrane fraction of the synovial cells (tryptic fraction) and a 1.6-fold elevation of glucosamine release into the medium was measured. The synovial fibroblasts show a higher (1.5-fold) glucose consumption and lactate production in the presence of diacetylrhein (2 x 10(-4) mol/l).
Adult↗