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Biomedical subjects

R N Thompson

Publications and source records attributed to R N Thompson.

25 records · Page 2Linked to original sources
PubMed1984

A controlled two-centre trial of parenteral methotrexate therapy for refractory rheumatoid arthritis.

Forty-eight patients with rheumatoid arthritis refractory to other treatments were studied in a placebo controlled trial of methotrexate (MTX) in 2 institutions. Once weekly for 6 weeks, the patients were injected with placebo (Group 1), MTX 10 mg (Group 2), or MTX 25 mg (Group 3). Then, for the next 6 weeks, Group 1 received MTX, either 10 or 25 mg/wk, and Groups 2 and 3 continued their same dose. Adverse reactions necessitated change from 25 mg to 10 mg in some patients, but no major side effects of MTX were noted. At 6 weeks, the effect of the 2 MTX doses did not differ significantly but patients on MTX had fared significantly better (p less than 0.005 - less than 0.001) than those given placebo. At 12 weeks, all indices showed significant improvement in Group 1 and maintenance or enhancement of the improvement in Groups 2 and 3. We conclude that weekly low dose MTX therapy is efficacious for refractory rheumatoid arthritis.

Adult↗
PubMed1975

Certain non-auditory physiological responses to noises.

The non-auditory physiological effects of extended exposure of pilots to high intensity noise were investigated. The health records of 22 professional pilots (FAA) were examined for recorded measurements of heart rate, systolic and diastolic blood pressure, serum cholesterol, and glucsoe. These data were compared to records of the same measurements from 29 non-flying FAA personnel of the same age, social and economic status as the pilots. The yearly means for each parameter were analyzed for changes with time, within the same population, and for differences between the two study groups. Audiometric histories were tabulated and compared, and noise levels inside aircraft were determined. Although it was demonstrated that FAA pilots were exposed to high occupational noise levels there was no indication that their exposure produced any significant non-auditory physiological response.

Aerospace Medicine↗
PubMed1975

The effects of broadband noise on the cardiovascular system on normal resting adults.

Blood pressure, pulse rate and pulse pressure were determined at 2-minute intervals on 20 healthy subjects while they were exposed to 91-dBA continuous broadband noise for 1 hour. Control data were obtained by replication without the noise. The noise produced no statistically significant changes in any of the cardiovascular parameters under study.

Adolescent↗