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Biomedical subjects

R Nardi

Publications and source records attributed to R Nardi.

At least 19 recordsLinked to original sources
PubMed1997

Emergency medical services in mass gatherings: the experience of the Formula 1 Grand Prix 'San Marino' in Imola.

Mass gatherings are special situations for which mass medical care must be preplanned. Acute emergencies occur at public gatherings and medical coverage on site has proven benefit. Responsibility of general plan, management of specific problems, transport planning, communications system, guidelines and protocols, special situations management, ancillary supports, sources of extra help for unforeseen needs are the most important items to consider. In mass gatherings the whole emergency medical service (EMS) planning and management has to depend on the emergency department direction, with its authority on all aspects of patient care in the EMS system. This report concerns the planning of EMS and of medical care in a situation at risk for mass casualties at the Formula I Grand Prix-Championship Racing 'San Marino' of Imola.

Automobiles↗
PubMed1995

Computerized guidelines for preventative care in general practice.

Computer-based guidelines for preventative care is an example of the way in which protocols can be put to use in an effective and useful way. However, computerised medical protocols will only be used on a large scale if they are integrated with the computer-based medical record. The AIM-project ISAAC is working on the development of integrated tools for use in Primary Health Care, and especially General Practice. One of the tools under development is prevention. In this article, prevention is used as an example of the implementation of protocols. After a short definition of prevention, the implementation of preventative modules (or protocols) in the ISAAC GP information system is discussed. There are several conditions or critical factors if the implementation of prevention (and protocols) in a GP information system and in a GP practice is to be successful. In the discussion, some of the opportunities that are emerging with the use of information systems and telematics in primary health care are also discussed, together with the potential of ISAAC and the crucial role that must be played by healthcare providers.

Europe↗
PubMed1993

[The assessment of glucose tolerance in hypertensive subjects treated with amlodipine].

The authors studied the side effects of amlodipine on glucose metabolism, carrying out an oral glucose tolerance test before and after 8-10 days of treatment, in a group of subjects with normal glucose tolerance. No significant variation in the average plasma glucose and insulin levels was observed. Nevertheless, in some cases, during amlodipine therapy, a decrease in glucose plasma level was found.

Amlodipine↗
PubMed1990

The histologic development of acid-induced esophagitis in the cat.

Acute reflux esophagitis in man is characterized histologically by infiltrates of segmented leukocytes, epithelial proliferation, and ulcers. Our feline model, which includes each of these features, is produced by the infusion of 0.1 N HCl at a rate of 1 ml per min into the distal esophagus of adult cats for varying periods of time. Our histologic scoring system includes both the intensity and the distribution of four morphologic features, namely basal cell hyperplasia (BCH), intraepithelial segmented leukocytes (IEL), subepithelial leukocytes (SEL), and ulcers. Each of these four categories are scored from 0 to 4, with a potential score of 16. We evaluated the effects of duration of acid exposure by infusing cats with HCl for 5 min (N = 4), 15 min (N = 12), 20 min (N = 12), and 30 min (N = 6), followed by autopsy 24 h later. Mean scores (+/- SE) were as follows: 5 min, 3.0 (+/- 1.7); 15 min, 9.0 (+/- 1.0); 20 min, 11.17 (+/- 1.06); 30 min, 15.17 (+/- 0.54). Differences between 5 and 15 min, 15 and 30 min, and 20 and 30 min were significant (P less than 0.05). Basal cell hyperplasia appeared to be the most sensitive marker of acid injury; ulcers denoted severe injury associated with longer exposure periods. Although an occasional eosinophil was seen, the majority of the segmented leukocytes were neutrophils. We also studied healing histologically by examining cats at 1 d (N = 6), 2 d (N = 6), 3 d (N = 11), and 4 d (N = 6) after a 30 min exposure to HCl.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1987

Ranitidine therapy for gastroesophageal reflux disease. Results of a large double-blind trial.

In a multicenter, double-blind trial, 284 patients with gastroesophageal reflux disease were evaluated before, during, and after six weeks of treatment with either placebo or ranitidine (150 mg twice daily). Randomization resulted in two comparable patient groups. Ranitidine treatment was significantly more effective than placebo treatment in decreasing the frequency and the severity of heartburn during both daytime and nighttime assessment periods. There was a significant correlation between improvement in heartburn symptoms and decrease in antacid consumption; hence, patients receiving ranitidine consumed significantly fewer antacid tablets. Among patients with endoscopic esophagitis at baseline, the overall change in endoscopic classification after six weeks of therapy was significantly better for the ranitidine-treated patients. The ranitidine-treated group had less evidence of erosions and ulcerations as well as greater healing. There were no differences between the groups with respect to changes in esophageal mucosal sensitivity to acid perfusion or changes in histologic grading of esophageal mucosal biopsy specimens. The ranitidine safety profile was similar to that of previous studies. We conclude that, in patients with gastroesophageal reflux disease, ranitidine therapy, 150 mg twice daily, markedly reduced the heartburn symptoms of reflux disease and significantly improved the endoscopic appearance of the esophageal mucosa.

Adult↗
PubMed1987

Do endoscopic findings influence response to H2 antagonist therapy for gastroesophageal reflux disease?

As part of a multicenter trial evaluating ranitidine in the treatment of gastroesophageal reflux disease, the therapeutic responses of patients with and without abnormal endoscopic findings were evaluated. All patients were randomized to either placebo or ranitidine (150 mg bid) treatment groups. The treatment interval was 6 wk. Thirty-seven percent of 283 patients enrolled in the trial had normal baseline endoscopy. Compared to the placebo group, 147 evaluable ranitidine patients with abnormal endoscopy displayed a marked and rapid symptom reduction which was sustained throughout the last 4 wk of therapy. Despite randomization of endoscopically normal patients, those treated with ranitidine had significantly more heartburn at baseline. However, the 89 evaluable ranitidine-treated patients with normal endoscopy also experienced a marked and rapid reduction in heartburn at the end of 1 wk. The symptomatic improvement in the endoscopically abnormal ranitidine patients was significantly greater (p less than 0.05) than that observed in the endoscopically normal ranitidine group. Since both groups fared better on ranitidine than placebo, the results of this study indicate that ranitidine is an effective treatment for patients with heartburn symptoms and documented esophageal acid sensitivity whether or not endoscopic parameters for esophagitis are present.

Adolescent↗
PubMed1986

Compliance and control: issues in group training for diabetics.

When patients in treatment do not comply with medical directives, the most competent health care may go for naught and patients' well-being may be jeopardized. By focusing on the links between assertiveness and coping skills and compliant behavior, the group program described here increased compliance as well as self-confidence in diabetic group members.

Adult↗
PubMed1985

Gammaglobulins and immunocomplexes in aqueous humor and serum of patients with senile cataract.

The authors have measured the gammaglobulins and the immunocomplex levels (CIC) in aqueous humor and serum of 14 patients (3 males and 11 females) over 50 years old, who were affected by different types of cataract. Even if the authors have examined a limited number of samples, the results confirm the previous data which also showed very low levels of IgG, IgA, IgM, IgE, CIC in aqueous humor.

Aged↗
PubMed1982

[What is in the future for geriatrics? I].

The authors, after an evaluation of the historical course of the geriatrics in England and its contents, point out the importance of this specialty from a demografic, economical, social, epidemiological and cultural point of view.

Aged↗
PubMed1982

[What is in the future for geriatrics? II].

The authors point out the importance of geriatric medicine in the hospital in its traditional goals and in some new proposals: geriatric case finding, general practitioner's education, teaching in nursing schools, family education, pre-retirement courses etc.

Aged↗
PubMedDate not supplied

Stimulation of gallbladder emptying by intravenous lipids.

BACKGROUND: Few studies have dealt with the effect of i.v. administration of lipids on gallbladder emptying, and the results have been conflicting. METHODS: Five healthy volunteers, three women and two men, aged 26 to 54 years, (mean, 29 years) were studied. Gallbladder emptying was assessed by means of real-time ultrasonography. RESULTS: In all subjects, the infusion of a 10% fat emulsion (Intralipid; Kabivitrum, Stockholm) over 3 hours caused a reduction in gallbladder volume. This effect was statistically significant at about 80 minutes of lipid infusion and became progressively more marked as the infusion progressed, reaching a reduction of approximately 30% during the third hour of infusion. A significant relationship (p < .001) was found between the concentration of serum triglycerides and the degree of gallbladder volume decrease. In control studies, infusion of physiologic saline containing glycerol, the excipient of intralipid, caused no significant changes in gallbladder volume. CONCLUSIONS: The results indicate that i.v. infusion of lipids is able to stimulate significantly contraction of human gallbladder.

Adult↗
PubMedDate not supplied

[Evaluation of the metacarpophalangeal profile (MPP) and of the dermatoglyphic pattern in Crouzon's syndrome].

The evaluation of metacarpophalangeal profiles (MPP) and dermathoglyphics patterns in two families affected by Crouzon's syndrome differing from genic expressivity, showed indicative findings for brachidactyly and "broad thumb and hallux" character. These abnormalities show Crouzon's disease not to be a true craniofacial dysostosis and number it among the wide sphere of syndromes presenting acrocephalic alterations.

Child↗