Biomedical subjects
R Nedden
Publications and source records attributed to R Nedden.
Comparison of ftorafur with 5-fluorouracil in combination chemotherapy of advanced gastrointestinal carcinoma.
The aim of the study was to compare the combination 5-FU-carmustine with ftorafur-carmustine in the treatment of advanced gastrointestinal cancer. To this end, a prospective, multicenter, randomized trial was initiated. Part I of this trial showed that similar response rates can be obtained with 5-FU-carmustine and ftorafur-carmustine in 109 patients (32.7% versus 26.3%). However, median survival was better in patients treated with 5-FU-carmustine (307 days versus 163 days). Part II of the trial revealed that neither a higher dosage of ftorafur (2 g/m2/day X 5 days) nor the addition of vincristine to both regimens changed the previously obtained results significantly. Again, median survival was found to be better in patients treated with 5-FU combination chemotherapy (304 days versus 144 days). Both the 5-FU and the ftorafur combination were tolerated reasonably well. The results suggest that combination chemotherapy including 5-FU is superior to ftorafur at the applied dosages in terms of survival.
Adjuvant chemotherapy with chlorambucil and 5-fluorouracil in primary breast cancer (Cooperative Study Heidelberg).
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[Renal excretion of gentamicin in man].
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[Quantitative relations between sero-chemical findings, fatty degeneration of the liver, alcohol drinking and body weight in a diabetic and non-diabetic collective with fatty degeneration of the liver].
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