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Biomedical subjects

R Nightingale

Publications and source records attributed to R Nightingale.

8 recordsLinked to original sources
PubMed1985

Oral cholecystography after liver transplantation in man.

Orthotopic liver transplantation has been performed in Cambridge since 1967. In order to prevent complications resulting from the biliary drainage techniques, the donor gall bladder was interposed between the donor and recipient common bile duct as a vascularised pedical graft. The procedure, first performed in 1976, has been employed where possible ever since. Six patients having had this technique performed, and who remained well six months to six years after liver graft, underwent oral cholecystography. Four patients opacified the interposed gall bladder and the gall bladder contracted in response to cholecystography or a fatty meal. This is the first time oral cholecystography has been used in these patients. The detail is such that it can be used to follow non-jaundiced liver-grafted patients.

Cholecystography↗
PubMed1978

The genesis and implementation of the Tasmanian obstetric survey.

The genesis and implementation of a continuing obstetric audit in Tasmania is described. The survey includes all public and private deliveries in Tasmania. Some of the early difficulties and their resolution are discussed. Because of its simplicity, the suggestion has been made that such a system would be suitable for a national audit.

Australia↗
PubMed1975

The effects of phytate on intestinal absorption and secretion of zinc, and whole-body retention of Zn, copper, iron and manganese in rats.

1. The inclusion of phytate (10 g/kg) in a purified diet containing zinc (15 mg/kg) fed to young male rats significantly reduced growth rate and food intake, and promoted a cyclic pattern of food intake characteristic of an uncomplicated Zn deficiency. The decreased growth rate could be accounted for by the reduced food consumption. 2. Rats maintained on a Zn-deficient diet (0.5 mg Zn/kg) were found to have a cyclic pattern of food intake and a very slight weight gain. The addition of phytate (10 g/kg) to the Zn-deficient diet promoted a net loss of mean body-weight. 3. Rats maintained on the Zn-supplemented diet containing phytate excreted significantly more Zn in their faeces than either pair-fed or ad lib.-fed control rats. Rats given the Zn-deficient diet supplemented with phytate excreted more Zn in their faeces than Zn-deficient control rats. 4. Dietary phytate significantly reduced the average daily accumulation (mug/d) and whole-body retention (relative to dietary intake) of iron, copper, manganese and Zn, whether or not the diet was supplemented with Zn. 5. The addition of phytate to the lumen fluid of ligated loops of rat duodenum maintained in situ significantly inhibited 65Zn absorption, compared with the control systems without added phytate. 6. Other studies using ligated duodenal and ileal loops indicated that Zn is secreted into the gut lumen and approximately one-third of this is normally reabsorbed. Recycling of endogenous Zn may be a significant process in the over-all body economy of this trace element. 7. The absorption of 65Zn added to the diet was significantly reduced by dietary phytate. Dietary phytate also reduced the biological half-life of body 65Zn from 61 to 211 h post-administration, possibly by inhibiting reabsorption of endogenous 65Zn and thus promoting a more rapid loss from the body.

Animals↗
PubMed1975

Effects of growth hormone on tissue metabolism in broiler chicks.

1. The effect of bovine growth hormone (GH) on cartilage, liver, muscle, pancreas and spleen has been investigated. 2. Tissue RNA was elevated in the liver, muscle and spleen of the GH-treated chicks while uptake of radioactive phosphate into RNA was stimulated for both liver and spleen. 3. The GH-treated chicks had an increased cartilage protein content together with a higher rate of incorporation of 14C-methionine pancreatic protein.

Animals↗