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R Nishida

Publications and source records attributed to R Nishida.

27 records · Page 2Linked to original sources

Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum.

A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD50 = 95 micrograms/ml against UV-induced mutagenic E. coli WP2 B/r Trp-. Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300 micrograms/ml.

Antimutagenic Agents↗

Some chemical transformations of 6-alkynylated purines.

6-Alkynylated purines were conveniently transformed to the corresponding 6-alkyl- and 6-alkenylpurines by three methods: (i) hydrogenation with 10% palladium-carbon or palladium acetate-sodium borohydride, (ii) addition of hydrogen halides or water and (iii) formal addition of diethylamine to the triple bond. Some of the products exhibited strong cytokinin activity.

Alkynes↗