[Wolman's syndrome].
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Biomedical subjects
Publications and source records attributed to R Nolte.
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Neonatal sleep myoclonus documented polygraphically during the second month of life and subsequent development of a seizure disorder are reported in a 3-year-old boy. Several generalized tonic-clonic seizures associated with febrile illnesses occurred during the first year of life; astatic and myoclonic attacks began at age 13 months. A complex partial seizure occurred for the first time at age 3 years. Differential diagnosis of age-related generalized myoclonic epileptic syndromes and various forms of neonatal myoclonus were considered in this unusual case.
The antiretroviral drugs azidothymidine (AZT) and 9-(-2-phosphonyl-methoxyethyl)adenine (PMEA) were individually tested for prevention of simian immunodeficiency virus (SIVmne) infection in macaques (Macaca fascicularis). Macaques were pretreated with either drug before inoculation with SIVmne, and drug treatment was continued for four weeks. The virus, antibody, and clinical status of the macaques was monitored for up to 36 weeks following inoculation. While AZT prophylaxis resulted in reduced virus load in some macaques, PMEA prophylaxis was highly efficacious in preventing acute SIVmne infection.