Biomedical subjects

R Novak

Publications and source records attributed to R Novak.

111 records · Page 7Linked to original sources

PubMedDate not supplied

[Cochlear responses to dynamic click pattern in the guinea pig].

Fast cochlear adaptation expressed as the percent of inhibition of the summed action potential, has been studied from the guinea pig cochlear responses to click trains, ramps, and steps in both directions. The transition time function of adaptation to constant click trains does not depend on the click strength, but rather on the click interval. At the background of steady state adaptation, click steps produce only transient changes of the adaptive state, opposite to step direction. Compared with constant train stimulation, adaptation is enhanced by descending click ramps, and diminished or reversed (near threshold) by ascending ramps.

Acoustic Stimulation↗

PubMedDate not supplied

Trisomy 8 is a characteristic finding in pleuropulmonary blastoma.

The cytogenetic findings in pleuropulmonary blastoma (PPB) have not been widely studied and reported and are of interest in view of the implications that PPB has for additional tumors in the patient and the patient's relatives. Using standard tumor cytogenetic methodology, we investigated three cases of PPB encountered in our institution over a 5-year period. Trisomy 8 was the only karyotypic abnormality in a localized type 2 PPB and was present with other abnormalities in another type 2 PPB and a massive type 3 PPB. Review of the literature yielded three additional karyotyped PPBs; all had trisomy 8 as part of the abnormalities detected. Trisomy 8 appears to be a characteristic of PPB and may be related to the development of PPB and related tumors.

Chromosomes, Human, Pair 8↗

PubMedDate not supplied

In situ hybridization on blood smears for diagnosis of chicken anemia virus in broiler breeder flocks.

Chicken anemia virus (CAV) infection was suspected in progeny from broiler breeder hens raised in a location that was geographically different from where most pullets were raised for one Georgia production company. These breeder pullets were raised in new or relatively new houses. Progeny from these pullets experienced a 10-fold increase in average daily mortality over progeny from flocks raised in established breeder houses. Lesions in the broilers included severe necrotizing dermatitis, pale bone marrow, and small thymus glands. Infection with CAV was confirmed in the breeders by enzyme-linked immunosorbent assay, indirect immunofluorescence, and in situ hybridization on peripheral blood smears. The in situ hybridization identified three broiler breeder flocks that were actively infected with CAV and were probably the source of infection in broiler flocks.

Animals↗