Biomedical subjects

R Novaković

Publications and source records attributed to R Novaković.

At least 19 recordsLinked to original sources

PubMed1995

[Relation between pyloric dysmotility and serum levels of gastrin, somatostatin and vasoactive intestinal polypeptide in patients with non-insulin dependent diabetes mellitus].

Serum levels of gastrin, somatostatin and vasoactive intestinal polypeptide were evaluated in 105 noninsulin dependent diabetics (25 of them had a pyloric dysfunction). The serum levels were determined by RIA and blood was taken before and after the test meal. The basal gastrin level was significantly higher in patients with the pyloric dysfunction (p < 0.001). 45 minutes later the serum levels of vasoactive intestinal polypeptide and somatostatin were significantly higher in diabetics with the pyloric dysfunction (p < 0.001). The serum levels of gastrin, somatostatin and vasoactive intestinal polypeptide were impaired in diabetics with the pyloric dysfunction and might be associated with its pathogenesis.

Diabetes Mellitus, Type 2↗

PubMed1994

An expert system approach for the objective interpretation of serum tumour marker levels.

The aim of our work was to study specific aspects of statistical Weinstein-Bayes's analysis in order to find the most suitable program for presenting our results and for obtaining information which could be used as a guide in the clinical decision-making process. Our efforts resulted in a computer processing system based on modified Weinstein-Bayes receiver operating characteristics (ROC) analysis. The data analysis provides numeric values of sensitivity, specificity, positive predictive value and negative predictive values as output tumour marker databases, which would serve as graphic input. It becomes possible to plot the ROC curve as a graphical distribution of tumour marker levels. The computer program also allows the estimation of the potential utility of the serum tumour marker measured in patients with various diseases, simultaneous determination of serum tumour markers in diseased patients, and the real value of each serum tumour marker level in diseased patients.

Adenocarcinoma↗

PubMed1994

[Association of autonomic neuropathies and gastrointestinal peptides in non-insulin dependent diabetics].

Basal and postprandial levels of gastrin, somatostatin, vasoactive intestinal polypeptide (VIP) and pancreatic polypeptide (PP) were followed up in 105 patients with non insulin dependent diabetes mellitus (20 with autonomic neuropathy only, 35 with peripheric neuropathy only, 30 with autonomic and peripheric neuropathy simultaneously and 20 without any sign of neuropathy) and in the control group of 40 individuals. Serum levels of gastrin, somatostatin, VIP and PP are determined by a RIA (used kits of Prof. SR Bloom, Hammersmith Hospital, London). The results of investigation showed significantly higher basal and postprandial levels of gastrin and VIP in patients with autonomic neuropathy in comparison with the group without neuropathy and with the control group (p < 0.001). The serum levels of somatostatin did not differ significantly between the groups of diabetics with and without neuropathy. Basal level of PP was significantly lower and postprandial PP levels remained low in patients with autonomic neuropathy in comparison with the group without neuropathy (p < 0.001). We postulate that basal and postprandial gastrin and VIP levels raised secondary to partial vagotomy in diabetics with autonomic neuropathy. Measuring PP serum levels in diabetics after a protein rich meal can be useful to check vagus nerve function in the gastrointestinal tract in order to detect autonomic neuropathy.

Adult↗

PubMed1993

The evaluation of tumor markers levels in determination of surgical procedure in patients with gallbladder carcinoma.

In purpose of early diagnosis of gallbladder carcinoma, the serum levels of tumor markers CA 72-4, CA 19-9, CEA, AFP, Ferritin and beta HCG were determined in 124 patients with benign and malign diseases of gallbladder, before and 10 days after the operation. The most important clinical significance have CA 72-4 and CA 19-9, which are increased in Ca in situ and carcinoma of the first stage. These early stages of carcinoma cannot be diagnostified by preoperative echotomography, but radical operation is possible with recover by all means. These two tumor markers should be attended in risk group of patients for rising gallbladder carcinoma: calculosis and polyposis. The rest of tumor markers are increased in progressive carcinoma with infiltration of surrounding tissue and metastases.

Antigens, Tumor-Associated, Carbohydrate↗

PubMed1993

The importance of monitoring colorectal adenomas by tumor markers (ROC analysis).

Are the increased values of specific tumor markers significant in monitoring colorectal adenomas at the beginning of malignant alteration? Tumor markers (CEA, CA 19-9 and CA 72-4) were determined in sera by IRMA kits. The increased levels of tumor markers CEA and CA 19-9 were statistically very significant in patients (28) with colorectal adenomas at the beginning of malignant alteration and in the group with colorectal adenocarcinomas (96). By ROC analysis the sensitivities, positive predictive values and negative predictive values of CEA and CA 19-9 were quite acceptable with high accuracies for all determined tumor markers in colorectal adenomas at the beginning of malignant alteration. Those findings suggest the importance of monitoring of colorectal tumours and precancerouses by tumor markers serum levels and it confirms the usefulness of counting results by ROC analysis.

Adenocarcinoma↗

PubMed1984