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Biomedical subjects

R O Gustafson

Publications and source records attributed to R O Gustafson.

8 recordsLinked to original sources

Evaluation of posttonsillectomy hemorrhage and risk factors.

BACKGROUND: A 13-year retrospective study was undertaken to determine the incidence of posttonsillectomy hemorrhage, to evaluate potential risk factors, and to assess the efficacy and safety of ambulatory tonsillectomy. METHODS: From January 1985 to December 1997, 4662 patients underwent tonsillectomy at our institution. Ninety patients with posttonsillectomy bleeding were identified. For each patient with posttonsillectomy bleeding, 2 nonbleeding control subjects were selected and matched by age and sex to evaluate potential risk factors. RESULTS: Age was the only factor found to be statistically significant among the bleeding patients and the control group. The highest incidence (3.61%) of posttonsillectomy hemorrhage occurred in patients 21 to 30 years of age. In our experience, secondary hemorrhage was more common than primary hemorrhage, presenting most frequently on postoperative days 5 to 7. CONCLUSIONS: The incidence of posttonsillectomy bleeding in this review was 1.93%, and about half (47%) of the patients with posttonsillectomy hemorrhage returned to the operating room for hemorrhage control. The highest incidence (3.61%) of posttonsillectomy hemorrhage occurred in patients 21 to 30 years of age. Patients with posttonsillectomy hemorrhage, regardless of management, had a 12% incidence of subsequent hemorrhage. We found no difference in the incidence of posttonsillectomy bleeding between outpatient and inpatient procedures.

Adolescent↗

Complications of malpositioned Jones tubes.

A Jones tube is an effective lacrimal drainage bypass device often associated with post-operative problems. Unsuspected migration of the tube may cause signs and symptoms that are not immediately identified with the prosthesis. Malposition of Jones tubes in three patients resulted in the following complications. The first patient had persistent episcleritis and atypical facial pain and numbness caused by migration of the tube against the globe and into the nasal septum. Bilateral tubes in the second patient were improperly oriented, causing severe scleral erosion and ulceration. The third patient's bilateral tubes migrated through the conjunctiva into the subcutaneous tissues and were manifested as lower eyelid inflammatory masses. Placement of a Jones tube requires long-term maintenance by the physician and the patient.

Adult↗

The clinical behavior of inverting papilloma of the nose and paranasal sinuses: report of 112 cases and review of the literature.

Between 1944 and 1987, 112 patients with inverting papilloma of the nasal cavity were treated. The average duration of follow-up for this population was 6.2 years. The most common symptoms were nasal obstruction and history of previous surgery for nasal "polyps". Recurrence rates were lower when treatment consisted of lateral rhinotomy with medial maxillectomy (14%) vs. transnasal operation with a sinus procedure (35%) or transnasal operation alone (58%). Recurrence rates between men and women were not significantly different when treatment methods were analyzed; however, a higher-than-expected association with tobacco usage was noted. Eight (7%) of the 112 patients had associated nasal carcinoma. Current treatment is lateral rhinotomy with medial maxillectomy to prevent troublesome and potentially malignant recurrent disease.

Adolescent↗

Office endoscopy--when, why, what, and how.

Comprehensive diagnostic nasal endoscopy is a relatively recent advance in the office practice of rhinology. The examination is performed most commonly with 4.0-mm telescopes (0 and 30 degrees) and 2.7-mm telescopes (30 and 70 degrees). Nasal endoscopy provides the rhinologist with unparalleled visualization with brilliant illumination of the nasal cavity which permits more accurate diagnosis of nasal conditions. It also serves as an excellent teaching tool and source of photodocumentation.

Endoscopes↗

Upper aerodigestive tract manifestations of Behçet's disease: review of 30 cases.

Behçet's disease is a chronic inflammatory disorder of undetermined cause. The most frequent manifestations are aphthous ulceration of the upper aerodigestive tract, genital ulcers, ocular inflammation, and arthritis. Less frequent features include involvement of the CNS, thrombophlebitis, and large-vessel arteritis. Of utmost importance is the fact that aphthous ulceration of the upper aerodigestive tract will develop in all patients who have Behçet's disease; thus, they may come to the otorhinolaryngologist for evaluation. This disease must be distinguished from recurrent aphthous ulceration, herpes simplex infection, Stevens-Johnson syndrome, Reiter's disease, pemphigus, systemic lupus erythematosus, and Crohn's disease. Behçet's disease is diagnosed on the basis of clinical features; no specific laboratory abnormalities have been noted. The histopathologic perivasculitis is non-specific. Corticosteroid administration has been the most efficacious treatment. For serious complications, such as uveitis or meningoencephalitis, immunosuppressive agents can be used.

Adolescent↗

Immunologic studies on cancer of the upper aerodigestive tract.

Two interesting findings have emerged from these studies. First, the NK susceptibility of EBV-related cell lines is dependent upon the state of the virus within the cells. EBV-positive cells were more competitive than their EBV-negative counterparts, and induction of the viral cycle in the EBV-positive cells further increased their ability to inhibit NK reactivity against K562. The implications of this finding with regard to surveillance against, and treatment of, EBV-related disease were discussed. Second, the preliminary data concerning the NK status of patients with head and neck cancer appear interesting, with the patients falling into two relatively distinct clusters of either high or low reactivity. The significane of this clustering will be determined by enlarging the study sample and performing longitudinal NK studies of the patients.

Animals↗