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Biomedical subjects

R O Khamzamulin

Publications and source records attributed to R O Khamzamulin.

12 recordsLinked to original sources
PubMed1990

[Response of the cardiovascular system to acetylcholine test in patients with bronchial asthma].

The response of cardiovascular system to acetylcholine inhalation has been studied in 10 patients with bronchial asthma in remission. With the threshold dose of the drug, i.e. at less than or equal to 20% reduction of the forced expiration volume per 1 sec, there appeared increased cardiac beating and output, elevated pressure in the pulmonary artery, ECG sings of a sharp overload in the right atrium. The shifts in the cardiac function resulted from a fall in alveolar pO2 produced by acetylcholine-related bronchial obstruction and following hypoxic vasoconstriction of the lesser circulation. The findings emphasize the need in the cardiovascular system control when performing the acetylcholine test for bronchial reactivity.

Acetylcholine↗
PubMed1986

[Features of the ECG in acute altitude sickness].

Using the Minnesota Code, we analysed ECGs of 58 subjects with smooth adaptation to high altitude (3.600 m) and of 70 patients with acute mountain sickness. In both groups, the 30-day sojourn at high altitude was characterized by ECG signs of the right heart overload; these signs were more marked in patients with acute mountain sickness. It was demonstrated that baseline ECGs (recorded before the ascent) of subjects predisposed to the development of acute mountain sickness showed a higher incidence of right-ventricular hypertrophy, right-atrial hypertrophy, and tachycardia. These ECG features can be used in the prognosis of acute mountain sickness.

Acute Disease↗
PubMed1978

[Effect of obsidan on the cardiovascular system under conditions of high-altitude hypoxia].

The effect of beta-adrenergic block on the circulatory reactions of a human being induced by high altitude hypoxia was studied by multi-channel rheography and indirect determination of systolic pulmonary arterial pressure. In healthy people not subjected to a pharmacological effect, 25-day stay at an altitude of 3,200 m was marked by an increase in cerebral blood flow at the beginning of adaptation and the development of pulmonary hypertension the maximum signs of which were recorded during the first days in the mountains. Daily intake of 80 mg of obsidan begun 3 days before the ascent levelled out the adaptative increase in cerebral perfusion and intensified the marked character and stability of hypoxic pulmonary vasoconstriction. It is concluded that great care should be exercised in giving obsidan at high altitude to individuals with even latent forms of right ventricular pathology since under conditions of hypobaric hypoxia beta-adrenergic block increases the load suffered by the right ventricular myocardium.

Adaptation, Physiological↗
PubMed1976

[Clinical and instrumental characteristics of primary high altitude arterial pulmonary hypertension].

The clinical pattern of primary high altitude pulmonary arterial hypertension observed in permanent residents of mountain regions is described. The diagnostic value of some non-invasive instrumental methods in primary high altitude pulmonary artery hypertension is analysed: electro- and vectorcardiography, rheopulmonography, and indirect pulmonary artery pressure determination. It is suggested to distinguish the labile, stable and decompensated forms of the disease on the basis of its clinical and functional peculiarities. The criterion for the initial two forms consists in the persistence of the pulmonary artery pressure elevation, while the latter form is established when the high altitude cor pulmonale gets decompensated. Functional vasoconstriction of the pulmonary resistive vessels was shown to play an important role in the genesis of the disease: the administration of 0.5 mg of nitroglycerine and a 5-minute oxygen inhalation caused a positive dynamics in the indices of the pulmonary rheogramme and a reduction of the pulmonary artery pressure, which did not reach the level of the plane inhabitants, though.

Adult↗
PubMedDate not supplied

[The effect of verapamil on external respiratory function in bronchial asthma patients during high-altitude speleotherapy].

To study the effect of speleotherapy on external respiration (ER) in asthma, ER was investigated in 2 randomized groups of 20 asthma subjects each. Speleotherapy was conducted in 24-day courses in salt caves of Chon-Tuz (2100 m above the sea level). The overall exposure lasted 160 hrs. One of the groups was assigned to additional verapamil hydrochloride aerosol therapy (10 mg/day, days 10, 12, 14, 16, 18, 20, 22). Speleotherapy was found to initiate positive shifts in the external respiration function whereas verapamil hydrochloride to potentiate the observed beneficial rearrangement in asthma patients.

Adult↗
PubMedDate not supplied

[External respiratory function in healthy subjects under joint exposure to conditions of a central highlands and a salt mine microclimate].

Spirographic examinations have been performed in 20-25-year-old healthy men randomized into two groups. Group I subjects underwent a 24-day adaptation to the climate of moderate altitudes (2100 m above the sea level). In addition, group II subjects spent a few hours daily (day 5-23, altogether 170 hours) in a salt mine Chon-Tuz. It was found that in healthy men microclimate of a salt mine potentiated the adaptive changes of external respiration in moderate altitudes as shown by increased bronchial permeability and vital capacity indicating growing functional reserves of external respiration.

Adaptation, Physiological↗
PubMedDate not supplied

[T- and B-components of immunity in acute altitude sickness].

Immunological aspects of the adaptation process were investigated in 57 male test subjects that stayed for 30 days at an altitude of 3600 m above sea level (Eastern Pamir Mountain Range). The uneventful development of adaptation was accompanied by a short-term decrease in the number and activity of T-lymphocytes. An acute mountain disease led to a distinct deficiency of T-cell immunity which still persisted on test day 30. Besides, the content of zero cells in circulating blood was increased and the blast-transformation reaction of lymphocytes to concanavalin A was inhibited. Prior to the ascent the test subjects who were susceptible to the acute mountain disease showed a lower content of T-lymphocytes and a higher content of zero cells in circulating blood.

Acclimatization↗
PubMedDate not supplied

[Cardiovascular function in acute mountain sickness].

Fifteen subjects with uneventful adaptation and 28 subjects with acute high mountain sickness were kept at an altitude of 3600 m. Prior to the exposure all the test subjects, aged 18-20, were essentially healthy. As compared to the controls, the subjects with acute high mountain sickness showed a greater increment in heart rate, blood pressure in the brachial artery, pulmonary hypertension and vasoconstriction. It was found that the subjects susceptible to acute high mountain sickness exhibited (at sea level) higher values of heart rate and R wave in the ECG II lead and lower systolic pressure in the brachial artery. These findings can serve as predictors of acute high mountain sickness.

Acute Disease↗