Biomedical subjects

R O Moore

Publications and source records attributed to R O Moore.

13 recordsLinked to original sources

PubMed2003

Importance sampling for noise-induced amplitude and timing jitter in soliton transmission systems.

We discuss the application of importance-sampling techniques to the numerical simulation of transmission impairments induced by amplified spontaneous emission noise in soliton-based optical transmission systems. The method allows one to concentrate numerical simulations on the noise realizations that are most likely to result in transmission errors, thus leading to increases in speed of several orders of magnitude over standard Monte Carlo methods. We demonstrate the technique by calculating the probability distribution function of amplitude and timing fluctuations.

Journal Article↗

PubMed1996

Differential expression of AF4/FEL mRNA in human tissues.

This manuscript reports the differential expression of the AF4 gene among human tissues. AF4 mRNA is highly expressed in normal placental tissue which correlates with the newborn age of patients presenting with leukemia characterized by the MLL/AF4 gene rearrangement.

Base Sequence↗

PubMed1995

Molecular analysis of infant acute lymphoblastic leukemia: MLL gene rearrangement and reverse transcriptase-polymerase chain reaction for t(4; 11)(q21; q23).

Molecular techniques to detect MLL (11q23) and AF-4 (4q21) gene rearrangements are being evaluated for use in stratification of patients into prognostic groups. We studied 15 cases of infant acute lymphoblastic leukemia (ALL) with Southern blotting for MLL gene rearrangement and reverse transcriptase-polymerase chain reaction (RT-PCR) for t(4;11) fusion transcripts and compared the results to cytogenetic and clinical data. Our results indicate that classic t(4;11)(q21;q23) translocations are detected by RT-PCR; however, unusual 4;11 translocations still require additional investigation. We also extended and updated our original study of MLL gene rearrangement in infant ALL to 40 patients with longer follow-up and show that the group with germline configuration of the MLL gene continues to have an excellent outcome. The results of salvage therapy (bone marrow transplantation or chemotherapy) suggest that transplant may show advantage. Preliminary results of the use of RT-PCR to assess minimal disease are also reported.

Antineoplastic Combined Chemotherapy Protocols↗

PubMed1978