Biomedical subjects
R O Walters
Publications and source records attributed to R O Walters.
Effect of tolazoline in severe hyaline membrane disease.
Tolazoline hydrochloride was given as a pulmonary vasodilator to 20 preterm infants with severe hyaline membrane disease requiring mechanical ventilation who developed persistent severe hypoxaemia. The drug was only given when deterioration persisted despite changes in ventilation techniques and thus there were no control infants. A significant improvement in arterial oxygenation was observed, particularly in those infants without intracranial haemorrhage or pneumothroax. Nine of 10 infants who had an obvious clinical response to tolazoline survived, whereas only 2 survived out of 10 who failed to respond, both being subsequently shown to have pneumothoraces. There appears to be a place for the use of tolazoline in a severely hypoxaemic infant with hyaline membrane disease who is being ventilated and in whom arterial oxygenation cannot be improved by further increase in the inspired oxygen concentration or by alteration of ventilator settings, provided pneumothorax has been excluded.
Idiopathic hypoparathyroidism with extrapyramidal and myopathic features.
A case of idiopathic hypoparathyroidism and basal ganglia calcification with extrapyramidal motor and myopathic features is described. The extrapyramidal motor and myopathic features disappeared when normocalcaemia was restored with treatment, suggesting that they resulted from hypocalcaemia.
Acute splenic abscess due to Salmonella chester.
Explore the source record for details and available documents.