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Biomedical subjects

R O Weller

Publications and source records attributed to R O Weller.

At least 127 records · Page 7Linked to original sources

Syringomyelia produced by intramedullary fluid injection in dogs.

Acute cord cavities have been produced by injection of saline or cerebrospinal fluid into the spinal cords of five beagle dogs. The lesions resemble syringomyelia as seen in the human. The lesions are described and the significance of the findings in supporting a hydrodynamic concept for communicating syringomyelia in the human are discussed.

Animals↗

Intraneural neurofibromas involving the posterior interosseous nerve.

Two patients presented with a posterior interosseous nerve palsy with supinator weakness. In each case an intraneural neurofibroma was found proximal to the supinator tunnel with no other stigmata of von Recklinghausen's disease. Both tumours showed a whorl-like histological pattern that has been previously confused with onion-bulb structures in hypertrophic polyneuropathy. Electron-microscopy was useful for the pathological diagnosis. The prognosis and treatment of the lesions are discussed.

Adolescent↗

Histological reassessment of three kidneys originally described by Richard Bright in 1827-36.

Portions of kidney from three patients with renal disease that were originally described by Richard Bright between 1827 and 1836 have been preserved in the Gordon Museum at Guy's Hospital. Histological study has shown that two cases fall into the current diagnostic category of mesangiocapillary (membranoproliferative) glomerulonephritis. One of these patients had a five-year clinical history and died with chronic renal failure and uraemia. The other patient died after three to four months with a severe nephrotic syndrome. The third patient was a young woman with chronic "phthisis pulmonalis" and renal amyloidosis.

Adult↗