[Experimental study on the kinetics of kanamycin in the labyrinthine fluids].
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Biomedical subjects
Publications and source records attributed to R Oda.
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Electrolyte-induced myelinolysis was produced in rats to evaluate electrophysiological derangement in the brainstem. Auditory brainstem responses (ABRs) were used to assess the brainstem function. Rats treated with hypertonic saline for 2 days had normal interpeak latencies in ABRs. Rats treated with vasopressin-induced hyponatremia alone and those with hypertonic saline after 3 days of hyponatremia had significantly prolonged interpeak latencies between waves II-III and III-IV in ABRs. These prolongations indicate electrophysiological derangement of the upper pons and mesencephalon in hyponatremic rats as well as in rats with hyponatremia followed by hypernatremic myelinolysis. In view of these data, hyponatremia may be a prerequisite for electrolyte-induced myelinolysis and electrolyte derangements such as hyponatremia, and rapidly correcting hypernatremia may be the cause of electrolyte-induced myelinolysis in rats.
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This is a case report of a 19-year-old male with an unusual case of a complete sciatic nerve paralysis which happened during the treatment of posterior dislocation of the hip. It was presumed that open reduction played a role of a trigger for the sciatic nerve palsy; because an almost complete recovery was obtained by release of the nerve from the ectopic bone mass, it is reasonable to assume that paralysis developed from massive ectopic bone formation around the nerve.