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Biomedical subjects

R Oliver

Publications and source records attributed to R Oliver.

17 recordsLinked to original sources
PubMed1992

Health of the nation.

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Community Mental Health Services↗
PubMed1992

Minocycline slow-release formulation effect on subgingival bacteria.

The purpose of this study was to determine the microbiological efficacy of an adjunctive minocycline periodontal formulation delivered subgingivally. Subjects were systemically healthy but exhibited severe periodontitis; i.e., probing depths greater than 6 mm. The two study groups included individuals who received minocycline or a placebo periodontal formulation after root planing. Subgingival plaque samples were obtained at baseline; prior to treatment; and at 1, 3, and 6 months. Plaque was evaluated by darkfield microscopy and further analyzed for total dark-pigmented Bacteroides species, P. intermedia, P. gingivalis and Streptococcus, Actinomyces, Eikenella, Actinobacillus, Capnocytophaga, and Fusobacterium species using cultivable flora techniques. In addition, plaque was evaluated for yeast on a selective agar medium. When compared to the placebo, the minocycline group had significantly lower proportions of spirochetes at 1 and 3 months and lower proportions of motile rods at 3 months. Furthermore, when compared to the placebo group, the minocycline patients had lower mean proportions of dark-pigmented Bacteroides spp. and P. intermedia at 1 and 3 months as well as lower proportions of E. corrodens at 1 month. The minocycline group had significant decreases in proportions of spirochetes at 1 and 3 months, motile rods at 1 and 3 months, and increases in cocci at 1, 3, and 6 months when compared to baseline. In the placebo group, root planing was also effective at decreasing spirochetes at 1, 3, and 6 months, but with significant differences seen only at 3 and 6 months. However, the degree of reduction in spirochete proportions was greater in the minocycline group when compared with the placebo group.(ABSTRACT TRUNCATED AT 250 WORDS)

Actinomyces↗
PubMed1991

Orthodontic bonding using glass ionomer cement: an in vitro study.

The aim of this study was to investigate the in vitro 24-hour tensile/peel bond strength of glass ionomer cement (GIC) together with the amount of cement left attached to the enamel surface after bond failure. The effect of contamination with moisture during setting/hardening and changing the powder/liquid mixing ratio of the GIC was also studied. Five GIC's (Intact, Fuji II, Orthocem B, ChemFil II, and Ketac Fil[capsulated]) and one composite resin (Concise) were tested by bonding GAC eyelets, with a curved photo-etched base, to the buccal surface of human premolars. Bond strength testing was performed on an Instron 1185 testing machine and the amount of cement left attached to the enamel surface quantified using the ARI index. The tensile/peel bond strengths achieved with all the GIC's were significantly lower than the composite resin (P less than 0.0002). Increasing the powder/liquid ratio resulted, in general, in higher bond strengths, the increase being significant for Intact and Orthocem B (P less than 0.05). Protection from moisture did not significantly affect the bond strength with the exception of Fuji II, for which, there was a significant decrease when the material was mixed at the recommended powder/liquid ratio.

Acrylic Resins↗
PubMed1979

Nickel dermatitis.

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Dermatitis, Contact↗
PubMed1978

Acne vulgaris.

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Acne Vulgaris↗
PubMed1976

Culture conditions affect photoreactivating enzyme levels in human fibroblasts.

Photoreactivation of pyrimidine dimers in mammalian cells occurs under our experimental conditions but has not been observed under conditions used by others. We have tested three possible differences in experimental procedures including dimer separation and analysis methods, illumination conditions and cell culture techniques. We show that out methods of dimer separation and analysis indeed measure cis-syn pyrimidine dimers and give results in quantitative agreement with the methods of others. We find that while light pre-illumination of fibroblasts from the xeroderma pigmentosum line XP12BE or of normal cells does not affect the cellular capacity for dimer photoreactivation. However, we show that cell culture conditions can affect photoreactivating enzyme levels and thus, cellular dimer photoreactivation capacity. Cells grown in Eagle's minimal essential medium (supplemented with 15% fetal bovine serum) contain very low levels of photoreactivating enzyme and cannot photoreactivate dimers in their DNA; however, companion cultures maintained in Dulbecco's modified Eagle's minimal medium do contain photoreactivating enzyme and can photoreactivate cellular dimers.

Cell Line↗
PubMed1976

Photoreactivation of pyrimidine dimers in the DNA of normal and xeroderma pigmentosum cells.

Photoproducts formed in the DNA of human cells irradiated with ultraviolet light (uv) were identified as cyclobuytl pyrimidine dimers by their chromatographic mobility, reversibility to monomers upon short wavelength uv irradiation, and comparison of the kinetics of this monomerization with that of authentic cis-syn thymine-thymine dimers prepared by irradiation of thymine in ice. The level of cellular photoreactivation of these dimers reflects the level of photoreactivating enzyme measured in cell extracts. Action spectra for cellular dimer photoreactivation in the xeroderma pigmentosum line XP12BE agree in range (300 nm to at least 577 nm) and maximum (near 400 nm) with that for photoreactivation by purified human photoreactivating enzyme. Normal human cells can also photoreactivate dimers in their DNA. The action spectrum for the cellular monomerization of dimers is similar to that for photoreactivation by the photoreactivating enzyme in extracts of normal human fibroblasts.

Binding Sites↗
PubMed1975

An investigation of chromosome damage in Vicia faba root tips after exposure to 1-5 MHz ultrasonic radiation.

Roots of seedlings of Vicia faba were exposed to 1-5 MHz continuous-wave ultrasound at approximately 5 W cm-2 intensity, averaged over the dividing region of the meristem, thus producing considerable non-thermal cell damage and severe inhibition of root growth. No significant increase in the number of coventional chromosome aberrations was observed during the 26 hours after exposure, although a significant number of cells did show bridged, agglomerated or clumped chromosomes. It is concluded that after exposure to ultrasound, genetic damage in surviving cells is unlikely.

Chromosome Aberrations↗
PubMedDate not supplied

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