The incorporation of 3H-leucine into protein from anterior and posterior cerebellum, cerebral cortex and liver was studied in rats given 50% of calories as ethanol, brandy, whisky, gin, red wine or isocaloric amounts of glucose together with diets with moderate or low protein-vitamin content for 8--9 months. Higher incorporation rates were usually observed with higher protein-vitamin administration. Red wine and brandy rats usually had the highest, ethanol and gin rats usually the lowest incorporation rates. The incorporation rate thus increased with amount of congeners present.

Alcoholic Beverages↗

PubMed1978

Determination of fast-acting plasmin inhibitor (alpha2-antiplasmin) in plasma from patients with tendency to thrombosis and increased fibrinolysis.

The physiologically important alpha2-antiplasmin has been measured by aid of a chromogenic tripepetide substrate. Low values in patients' plasmas are found in situations with increased fibrinolysis such as streptokinase therapy and liver cirrhosis, whereas high values are found postoperatively, postpartum and after an acute thrombosis.

Acute Disease↗

PubMed1978

Changes in "routine laboratory tests" during abstinence after heavy alcohol consumption in chronic alcoholics.

Standard laboratory tests were studied in 61 male chronic alcoholics admitted for detoxication after a period of heavy alcohol consumption. Results obtained within three days after the end of the last debauche were compared with those obtained one week later. Almost half of the patients was considered to have thrombocytopenia, two thirds of the patients had subnormal serum urea values and more than two thirds of the patients were considered to have increased ASAT values. Abnormal values often normalized within one week after admission. Significant alterations within the reference limits were observed for hemoglobin, erythrocyte sedimentation rate, sodium, potassium and bilirubin. The latter test often showed strikingly low values after one week. Most of the aberrations and the changes could be related to details in the case histories.

Alcoholism↗

PubMed1978

Elimination of paracetamol in chronic liver disease.

Serum concentrations of paracetamol were followed after oral administration of the drug to 21 patients with liver cirrhosis, 4 patients with secondary liver cancer, and 15 hospitalized patients without clinical evidence of liver disease. The cirrhotic patients had 50 per cent longer half-lives of the drug. They also had significantly higher values of AUC during the first 360 minutes, in spite of almost identical means values of Cmax and tCmax. Significant differences in paracetamol elimination between cirrhotics with and without ascites, or between cirrhotic with and without porto-caval shunt could not be demonstrated.

Acetaminophen↗

PubMed1977

Serum lipids and lipoproteins during abstinence after heavy alcohol consumption in chronic alcoholics.

Serum lipids, liver function tests and liver histology were studied during a withdrawal period in sixty-one male chronic alcoholics with a well-documented earlier clinical history. In these alcoholics with a mean daily ethanol consumption of 340 g during the débauche, the FFA were initially high and decreased during the first week, concomitantly with an increase in serum triglycerides. 38% of the patients had a type IV hyperlipoproteinaemia with elevated serum triglycerides still after 17 days of abstinence. 51% were normolipidaemic at that time. The cholesterol content in the alpha-lipoproteins were initially elevated and normalized during the first week of abstinence. No relationships were observed between serum lipids and liver function tests or degree of liver steatosis or alcohol consumption. The present findings stress the importance of stating the duration of abstinence in studies of biochemical changes after withdrawal.

Adult↗

PubMed1975

Effect of long-term administration of different hard liquors and red wine on the rat liver. A histological and biochemical study.

Male rats were given 50 per cent of calories as ethanol, whisky, brandy, gin and red wine for 8-9 months together with moderate or low protein and vitamin supply. Histological studies at sacrifice failed to detect signs of hepatotoxicity, but biochemical studies indicated that at least red wine and whisky produced more undesirable effects on the liver than ethanol.

Alanine Transaminase↗

PubMed1975

Effects of long-term administration of alcoholic beverages on the kidney, heart, skeletal muscle and pancreas of rats. A histological study.

No pathological changes in the pancreas, kidneys or skeletal muscle were found in rats maintained for 8 to 9 months with a diet in which alcohol made up 50% of the total calories. An increase of the dietary fat content to 38% did not cause any fatty infiltration of the myocardium.

Alcohol Drinking↗