Biomedical subjects

R Osusky

Publications and source records attributed to R Osusky.

21 records · Page 2Linked to original sources

PubMed1988

[Luetic uveitis in a patient with AIDS. Case report].

We report on a 33-year-old male Turkish patient with primarily nonsuspect sexual behavior who presented with panuveitis unresponsive to therapy. HIV infection and secondary syphilis was diagnosed. The uveitis was the only manifestation of syphilis. Because of isosporiasis, an HIV infection of CDC class IV C1 was diagnosed. This is the second published case of acquired syphilitic uveitis in a patient with HIV infection. The diagnosis was delayed by a prozone phenomenon. Treatment with high doses of penicillin i.v. for 14 days led to complete recovery. Because the HIV infection may obscure the diagnosis of syphilis, this constellation will assume increasing importance with the growing number of HIV-infected patients.

AIDS Serodiagnosis↗

PubMedDate not supplied

Nocturnal dip in the optic nerve head perfusion.

PURPOSE: Many physiological parameters, including blood pressure, show circadian variations. Diurnal fluctuations of the optic nerve head (ONH) circulation have not yet been studied. The purpose of the present study was to determine the pattern of ONH blood flow variations over a 24-hour period in healthy subjects. METHODS: The subject group comprised 15 healthy volunteers (6 women, 9 men) aged 22 to 43 years (mean +/- SEM: 28.2 +/- 1.3 years). Blood flow in the ONH was measured by laser Doppler flowmetry (LDF) over a 24-hour period at 08:00, 12:00, 16:00, 20:00, 24:00 hours, and at 08:00 hours the following morning. RESULTS: ONH perfusion varied significantly over time. The mean LDF-flow during daytime ranged from 8.2 to 8.9 arbitrary units (AU) and fell at midnight to 7.1 AU (P =.0015). The mean LDF-volume during daytime was 0.23 to 0.24 AU and decreased at midnight to 0.20 AU (P =.04). The mean LDF-velocity ranged from 0.39 to 0.41 kHz with no significant differences at any time point. CONCLUSIONS: Our study in normal subjects reveals small mean changes of ONH perfusion during daytime and a significant reduction at night. The physiological and clinical relevance of the nocturnal dip in the ONH perfusion needs to be determined in future studies.

Adult↗

PubMedDate not supplied

Individual measurements of angiotensin II concentrations in aqueous humor of the eye.

The presence of constituents of the renin-angiotensin system (RAS) in ocular tissues and fluids suggests this system is involved in ocular physiology. Angiotensin II (AngII) is the main biological effector of the system, so we measured AngII in plasma and in aqueous humor of the anterior ocular chamber of patients undergoing cataract extraction. Untreated normotensive patients were compared with arterial hypertensive patients taking either diuretics which stimulate the RAS or angiotensin converting enzyme (ACE) inhibitors which reduce the production of AngII. Plasma levels of AngII were higher in patients on diuretics (5.46 +/- 1.04 fmol/ml; mean +/- SEM) than in untreated cataract patients (2.28 +/- 0.32 fmol/ml, p < 0.02), and were very low with ACE inhibitors (0.51 +/- 0.18 fmol/ml). In aqueous humor, AngII was measurable in 7 of 11 patients on diuretics (median 1.1 fmol/ml), and in 6 of 16 normotensive patients (median < 0.55 fmol/ml), but not in aqueous humor of 4 patients receiving enalapril or captopril. These results demonstrate the presence of AngII in the eye but do not exclude either its sequestration in the eye or local production. The possibility of individual measurements of intraocular AngII will permit more precise determination of its role in future studies.

Aged↗