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Biomedical subjects

R Ott

Publications and source records attributed to R Ott.

At least 19 recordsLinked to original sources
PubMed1992

Pain in extracorporeal shock-wave lithotripsy: a comparison of different lithotripters in volunteers.

The aim of the present study was to investigate pain sensations experienced during extracorporeal shock-wave application, comparing an electrohydraulic (MPL 9000; Dornier Medizintechnik, Germering, Germany), an electromagnetic (Lithostar Plus; Siemens, Erlangen, Germany), and a piezoelectric (Piezolith 2300; Wolf, Knittlingen, Germany) shock-wave system. In nine healty volunteers, three therapeutically used intensities were applied in a randomized order with each lithotripter (MPL 9000: 16, 20, and 24 kV; Lithostar Plus: settings 5, 7, and 9; and Piezolith 2300: settings 2, 3, and 4). The subjects received nine series of 20 shock waves amounting to a total of 180 shock waves per session. The treatment was performed under clinical conditions, and no premedication was given. A visual analog scale and the McGill Pain Questionnaire were used for assessment of pain. In addition, somatosensory evoked potentials caused by shock-wave stimulation were recorded. Some of the volunteers were unable to bear the pain caused by the highest shock-wave intensity of the electrohydraulic (n = 3) and the electromagnetic system (n = 4). Estimates using the visual analogue scale showed increased pain sensations with increasing energy settings for each lithotripter. The amplitudes of the somatosensory evoked potentials became larger, and latencies shortened with increasing stimulus intensities (P less than 0.05). Subjective estimates by means of the visual analogue scale (P less than 0.01) as well as the McGill Pain Questionnaire (NS) and the somatosensory evoked potentials (P less than 0.05) showed that stimulation by the piezoelectric lithotripter was less painful than stimulation by the two other generators.

Adult↗
PubMed1991

Total biliary protein, mucus glycoproteins, cyclic-AMP, and apolipoproteins in the gallbladder bile of patients with cholesterol stones and stone-free controls.

The concentrations of total protein, mucus glycoprotein, cyclic-AMP, and apolipoproteins A-I, A-II, and B were determined in the gallbladder bile of patients with cholesterol gallbladder stones and in stone-free controls. The total protein content was significantly increased in gallstone patients (2.03 +/- 0.6 versus 1.31 +/- 0.67 mg/ml; p less than 0.05), as was the mucus glycoprotein concentration (380 +/- 88.5 versus 128 +/- 57.2 micrograms/ml; p less than 0.05). The cyclic-AMP concentration in the gallbladder fluid was increased up to 91 +/- 20 pmol/100 microliters in the gallstone subjects, as compared with 46 +/- 26 pmol/100 microliters (p less than 0.01) in stone-free controls. Cyclic-AMP concentrations correlated positively with the glycoprotein content of the bile in cholesterol gallstone patients (r = 0.66; p less than 0.05). The apolipoprotein concentrations were determined by the radial immundiffusion technique. The corresponding values for patients with stones and controls were 7.5 +/- 0.8 versus 3.0 +/- 0.8 for Apo A-I (p less than 0.025), 10.4 +/- 0.6 versus 6.3 +/- 1.3 for Apo A-II (p less than 0.02), and 1.9 +/- 0.5 versus 1.6 +/- 0.2 mg/dl for Apo B (NS), respectively. Biliary proteins probably play an important role in the nucleation process during the pathogenesis of cholesterol gallbladder stones.

Adult↗
PubMed1991

In vitro fragmentation of gallstones: comparison of electrohydraulic, electromagnetic and piezoelectric shockwave lithotripters.

To compare the fragmentation efficiency of three different shockwave systems, 63 human gallstone triplets were disintegrated in vitro using an electrohydraulic (MPL 9000, Dornier), an electromagnetic (Lithostar Plus, Siemens) and a piezoelectric (Piezolith 2300, R. Wolf) lithotripter. Since each stone triplet was obtained from the same gallbladder, the concrements of one such set were identical in physicochemical parameters. According to the maximal diameter, the calculi were divided into group A (6 to 15 mm) and group B (16 to 30 mm). Shockwave application was terminated when residual fragments measured 4 mm or less. Forty-five triplets were fragmented at energy settings mainly used in clinical treatment of patients with gallbladder stones (MPL 9000: 20 kV; Lithostar Plus: setting 9 (maximal); Piezolith 2300: setting 3). The fragmentation endpoint was achieved in group A (n = 3 x 36) with the Piezolith 2300 after median 150 (range = 50 to 500) pulses and with the Lithostar Plus after 150 (50 to 750) pulses compared with 500 (50 to 1,500) pulses using the MPL 9000 (p less than 0.01). In group B (n = 3 x 9) the Lithostar Plus (median = 750, range = 250 to 1,250 pluses) required fewer discharges than the Piezolith 2300 (1,250, 250 to 2,500 pulses; p less than 0.05) and the MPL (1,500, 500 to 1,600 [upper limit] pulses; p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Cholelithiasis↗
PubMed1990

[Alternative treatment methods in complex fractures and fracture-dislocations of the anterior tarsus].

Obtaining and maintaining an anatomic reduction are the keystones in the treatment of severe midtarsal injuries to avoid long-term disability. The use of the small external fixator or the minidistractor allows an indirect reduction with careful management of the soft tissues. By leaving the external fixation for at least 8 weeks the important length of the medial and lateral longitudinal arch can be maintained. Further advantages are the postoperative observation of the soft tissues and circulation without cast immobilisation.

Adult↗
PubMed1978

Perichondro-cutaneous graft.

A perichondro-cutaneous graft uniquely provides skin cover with the potential of generating its own cartilaginous support. An initial laboratory investigation is reported, and various applications of this graft to reconstructive facial surgery are proposed. Several clinical cases are presented.

Adult↗
PubMed1978

[Hematuria].

Explore the source record for details and available documents.

Hematuria↗
PubMed1977

The development of intramedullary cavitation following spinal cord injury: an experimental pathological study.

It is concluded from this investigation that localised intramedullary cavitation will develop following non-disruptive spinal cord trauma if the magnitude of original trauma and resulting vascular damage is sufficient. Although an adhesive arachnoiditis also occurs with similar amounts of trauma, the initial vascular damage and subsequent reparative changes within the spinal cord appear to adequately explain the cavitation observed.

Animals↗
PubMed1976

Bladder and urethral recordings in acute and chronic spinal cord injury patients.

Three groups of patients with upper motor neuron lesions were studied. A first group consisted of 19 patients with complete lesions and 3 patients with incomplete lesions. All had an unbalanced bladder function which required surgical interventions. A second group consisted of 9 patients with chronic complete lesions who achieved balanced bladder function spontaneously. A third group consisted of 11 patients in the acute stage of injury. Polygraph recordings of pressure within the bladder, urethra, rectum and external anal sphincter were carried out with the help of video-tape monitoring and radiographic image intensification. Special catheter ballons with radiopaque markings were employed for pressure measurements. The behavior of the external urethral sphincter during spinal shock and the sequence of return of sacral somatic and visceral motor reflexes during recovery from spinal shock were investigated. It was shown that in spinal shock, the majority of patients retained sacral segment somatomotor reflex activity, in the absence of visceromotor activity, and that resistance values at the external urethral sphincter remained high. The highest resistance recorded in the membranous urethra was found to be located at the distal external sphincter, just before the bulb of the urethra.

Acute Disease↗
PubMed1975

Urinary manometry in spinal cord injury patients. External urethral sphincter pressure recordings before and after sphincterotomy.

Recordings of local pressure within the membranous urethra were performed in 15 male spinal cord injury patients before and after external sphincterotomy. Transurethral division of the external sphincter reduced the intraurethral pressure by 55% in the upper part of the membranous urethra and by 66% in the lower part. The local pressure within the membranous urethra seems to diminish in proportion to the importance of the incision of the urethral wall.

Humans↗
PubMed1975

Urinary manometry in patients with spinal cord injury: neurourological considerations in the rehabilitation of acute and chronic neurogenic bladder.

Recordings of pressure within the bladder, urethra, rectum, and external anal sphincter with image intensification and videotaping were carried out in spinal cord injury patients with complete and incomplete lesions, during spinal shock and in the chronic stage. The behavior of the external urethral sphincter and the somatic and visceral motor reflexes of the sacral segments were studied, during and after spinal shock. During spinal shock the majority of patients retained sacral somatomotor activity, in the absence of visceromotor activity, and resistance values at the external urethral sphincter remained high. Vascular oscillations were recorded in the membranous urethra. The highest resistance found in the membranous urethra was at the distal part of the external sphincter.

Acute Disease↗