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Biomedical subjects

R Otto

Publications and source records attributed to R Otto.

At least 19 recordsLinked to original sources

[Ultrasonically guided percutaneous fine-needle biopsy (author's transl)].

A new method is described of doing fine-needle biopsies, under continuous visual control with real-time ultrasonic guidance, of the neck, thoracic and abdominal regions. The method decreases the risk of needle puncture and improves the yield of material obtained. It is simple and hardly stresses the patient, pain being only slight and momentary. It can be easily repeated. It is particularly useful for amniocentesis in obstetrics because it employs the shortest possible pathway.

Abdomen

[The problem of the multifocal breast neoplasm].

Nowadays, it is accepted that mammary cancer does not represent a localized tumor only, but a bilateral disease of breast tissues. During a period of 6 years, bilateral manifestations of infiltrating cancer have been observed in 12.7% of all cases. 23.2% of all breast cancer patients had a unilaterial multicentric tumor. The implications of this phenomenon with regard to control and therapy are as follows: As early diagnosis of malignant breast tumors often is possible by means of mammography, this examination should be performed regulary in high-risk patients, especially in cases of known earlier malignancy of one breast. More radical surgery should have priority, in view of the frequently observed multicentricity of breast cancers.

Biopsy

[Erroneous diagnosis in superficial course of the aorta. Demonstration using ultrasound].

In hyperlordosis of the lumbar spine, the abdominal aorta becomes well palpable and behaves like a pulsating tumor in the lower abdomen. This normal finding often cannot be differentiated from pathologic changes by clinical investigation alone. Sonography offers a simple method, without risk, for the definitive diagnosis of the abdominal aorta.

Abdominal Neoplasms

Metabolic responses of females to high intensity interval training of different frequencies.

The purpose of this investigation was to examine the effects of frequency and distance of high intensity, interval training on females. Thirty-two females participated in an eight-week program of interval run training. Subjects were assigned to either a 2 day/week or a 4 day/week group, as well as a high intensity, short distance (50,101,201 meters), or high intensity longer distance (604, 805, 1208 meters) group. Estimates of training intensity were 170% and 130% Vo2max for the short and longer distance groups, respectively. Maximal and submaximal measures of oxygen consumption (Vo2), heart rate (HR), and venous blood lactic acid were determined prior to and following the training program. After training, there was a significant increase (P less than 0.01) in Vo2max (13%) (deltax = 0.32 1/min or 5.2 ml/kg.min). Maximal VE increased approximately 12% after training (P less than 0.01). Max HR, max lactic acid, and submax Vo2 were not altered by the training. However, HR submax decreased significantly (P less than .05) after training by approximately 6%. Analysis of coveriance indicated that these changes were independent of training frequency, distance, and intensity. It was concluded that the changes in aerobic power and submaximal HR of females are independent of frequency, distance, and intensity of high-intensity interval training programs.

Adult

Variable phenotypic expression of an X-linked recessive lymphoproliferative syndrome.

Investigation of a family with cancer in boys revealed that at least 20 males had the X-linked recessive lymphoproliferative syndrome. A variety of phenotypes occurred: aproliferative phenotypes consisted of aplastic anemia, agranulocytosis or acquired hypogammaglobulinemia; and proliferative phenotypes of B cells included disorders associated with the Epstein-Barr virus, American Burkitt's lymphoma, immunoblastic sarcoma of B cells, fatal infectious mononucleosis or plasmacytoma. The lymphoproliferative disorders observed in males could have resulted from an immunodeficiency to Epstein-Barr virus. The variable phenotypic expression could have resulted from individual differences in the viral dose, duration of exposure and age at which the boys were exposed to the virus. Aproliferative phenotypes such as acquired hypogammaglobulinemia could have ensued from excessive suppressor-cell activity on B cells, whereas proliferative phenotypes such as Burkitt's lymphoma or fatal infectious mononucleosis could have resulted from infection by Epstein-Barr virus and failure to stop proliferation of B cells.

Adolescent

[Possibilities and limits of xeroradiography. A statement (author's transl)].

Xeroradiography has proved to be of particular use for the examination of soft tissues. Due to great latitude and edge enhancement effect alterations of the splanchnocranium, the breast and the juxtaosseous soft tissues are especially well recognizable. Also for examination of larynx and trachea as well as certain soft tissues in the region of the neck this method is advantageous and proves its facilities to demonstrate diseases of the lungs and hilar region. On the contrary, alterations of the vertebral column, the basis of the skull and the abdomen cannot be examined by means of xeroradiography because of not justified radiation dosage. Xeroradiography offers no advantage for arthrography, angiography and examination of bones and skeletal parts of joints.

Adult

[The diagnosis of soft tissue alterations of the knee by means of xeroradiography (author's transl)].

Xeroradiography is a useful screening-method for the evaluation of soft tissue alterations in the region of the poplitea. It proves that recognition of Baker's cysts, aneurysms, and even tumours is possible due to morphological criteria which allow for differentiation to a degree. The conformation of a lesion by means of arthrography or angiography is not to be dispensed with, but xeroradiography permits the objective demonstration of a clinically uncertain alteration. This method has demonstrated its usefulness especially for the rheumatologist in the evaluation of Baker's cysts.

Humans