Pathological features of chronic pancreatic disease in Uganda.
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Biomedical subjects
Publications and source records attributed to R Owor.
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A study of arterial circles of Willis from a series of 715 consecutive autopsies in Ugandan Africans shows that severity of cerebral atherosclerosis increases with age. No significant difference exists between men and women nor among main tribal groups. The severity is less in Ugandan Africans than in United States blacks but is approximately the same in United States Caucasians. However, the Ugandan Africans show a more severe cerebral atherosclerotic involvement than do the Nigerians.
A unique case is described of a 21-year-old female with gonorrhea, condylomata acuminata of the vulva and the uterine cervix, a squamous-cell papilloma and precancerous changes in the cervix. In the observed lesion, a very gradual transition was seen from benign areas, displaying marked cytoplasmic vacuolization, to moderately dysplastic areas, with only slight vacuolization. Giant squamous cells with centrally located vesicular or hyperchromatic nuclei were a prominent feature of both the condylomatous and premalignant portions of the lesion. A geographic correlation was observed in the 18 districts of Uganda between the incidence of vulvar and vaginal condylomata acuminata and cervical cancer; the finding may include cervical warts since vulvovaginal changes often extend to the cervix uteri. In addition to the common flat condyloma, the acuminate variant may be a precursor of cervical cancer and progress to malignancy through the stage of a squamous-cell papilloma.