[Changes in cerebral vessels during experimental hyperlipidemia].
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Blood↗
Biomedical subjects
R P Chaĭkovskaia
Publications and source records attributed to R P Chaĭkovskaia.
[Pathology of the brain in Creutzfeldt-Jakob disease].
The autopsy cases of Creitsfeldt-Jacob disease (a sporadic form) are reported which were diagnosed clinically and supported by the data of biopsy and autopsy of the brain (classic triad: death of neurons, astrogliosis and spongiform degeneration of the gray substance of the cortex of brain hemispheres, preferentially), followed by clinical morphologic comparisons. The focal character of the disease was observed on the early stages of the disease, while diffuse alterations were found on the late stages.
Basal Ganglia Diseases↗
[In vivo diagnosis of Creutzfeldt-Jakob disease].
The paper presents the data concerning usage of some original method of vital laboratory diagnostics of Creutzfeldt-Jacob disease that belongs to the group of prionic diseases. The method consisted in the inoculation of inoculative culture of rat Gasser ganglion's neurinoma by biologic materials investigated (serum and clot of blood) with the following passivation and investigation of the contaminated culture by means of both morphologic and electron microscopic methods. As an example of vital verificated case the wide pathomorphologic analysis of the biopsy sample of brain was presented. Besides, the efficiency of the investigation of cognitive evoked potentials (P300) together with EEG was also demonstrated as the method of objectification of the development of dementia in this disease.
Brain↗
[Hypersomnic syndrome in circulatory disorders of the oral portions of the brain stem (clinico-morphologic observations)].
Hypersomnia is described in 11 patients who have had a cerebral circulation episode with prevalent localization of the lesion in the oral divisions of the brain trunk. Three morphological observations are presented: these were cases of bilateral affection of certain meso- and diencephalic structures, e.g. medial divisions of the thalami and the diencephalon cover with involvement of the grey matter of the Sylvian aqueduct into the process. The observations presented confirm the opinion that the nonspecific structures of the meso- and diencephalic region are a part of the complex cortico-subcortical system participating in maintaining the state of wakefulness.
Aged↗
[Recurrent brain infarctions in atherosclerosis and arterial hypertension].
In 100 cases of brain infarctions of different size and time caused by atherosclerosis and arterial hypertension, the infarctions were located in the territory of carotid arteries (44 cases), of vertebro-basilar system arteries (18 cases) and of both the systems (38 cases). The infarctions were repeated, multiple in 82 cases, single--in 18 cases. Atherothrombosis and atherostenosis, thromboembolism of the brain arteries from the heart are main pathogenetic factors. The phenomenon of "infarction in the infarction" is observed in the limits of one arterial pool.
Adult↗
[Hypertensive angio-encephalopathy and vascular dementia].
A clinicomorphological analysis of 60 postmortem cases with brain circulation disturbances against the background of arterial hypertension (AH) is performed. Lacunar infarcts, areas of incomplete necrosis and perivascular encephalolysis, small hemorrhages, criblures, persistent oedema and widespread spongiosis are found in the white matter (WM) of the brain in cases of AH of long duration with dementia. An important role in the WM lesions belongs to its ischemia due to hypertension angiopathy and disturbances of hemodynamics and liquor circulation. Complex of these lesions is called "hypertension leucoencephalopathy".
Adult↗
[Lifetime diagnosis of prion transmissive encephalopathies].
An original method for life-time diagnosis of Greutzfeldt-Jakob's disease, a neurodegenerative disease belonging to transmissive spongiform encephalopathies, is proposed. It consists in inoculation of the examined biological materials (blood serum and clot) into a continuous culture of the rat Gasser's node neurinoma, followed by passages and study of the inoculated culture by morphological methods and electron microscopy.
Animals↗