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Biomedical subjects

R P de Dycker

Publications and source records attributed to R P de Dycker.

10 recordsLinked to original sources
PubMed1992

[Treatment of primary therapy refractory choriocarcinoma using the EMA-CO protocol].

This is a report on a 33 year old patient with a metastatic gestational choriocarcinoma. The patient was hospitalized with the picture of a spontaneous left kidney rupture and nephrectomy was performed. Under primary mono-dose methotrexate chemotherapy, the patient showed rapidly progressive metastases in both lungs, liver, right kidney and soft tissue. With the use of multiple-chemotherapy, according to the EMA-CO scheme, we observed complete remission. To date, there has been no indication of any tumour recurrence.

Adult↗
PubMed1991

[Adjuvant chemotherapy in dysgerminoma].

This is a report on a young patient with dysgerminoma of the right ovary. Right-side adnexectomy and hysterectomy were performed initially. Due to the clearly elevated tumour marker levels, indicating an involvement of other germ cell elements, we opted for postoperative chemotherapy instead of radiotherapy. The follow-up included regular monitoring of the tumour markers. To date, there has been no indication towards tumour recurrence.

Adolescent↗
PubMed1990

[Spontaneous kidney rupture].

Two cases of spontaneous rupture of the kidney are reported and the literature is reviewed. The clinical and pathological features of this uncommon disease and its treatment are discussed. In the first case the cause of retroperitoneal bleeding was a renal carcinoma, while in the second it was the result of renal metastases from gestational trophoblastic disease. The most common symptoms are an acute onset of flank or abdominal pain, macroscopic hematuria and a drop in the hemoglobin level. Resistance or a mass can be palpated. Ultrasound and radiological examinations allow visualization of a tumor or hematoma and mostly reveal the etiology of hemorrhage. An exploratory operation is necessary for diagnosis, and primary nephrectomy should be seriously considered.

Adult↗
PubMed1989

[Spindle cell sarcoma of the female breast].

Malignant mesenchymal breast tumors are extremely rare. Without cystosarcoma phylloides, the frequency of primary sarcomas is 0.6% of all neoplasms of the breast. A case is reported of an adolescent girl, and the diagnostic features and treatment are discussed in correlation to the literature data. The pathogenesis of the sarcoma and the possible connection with Epstein-Barr viral infection is analysed. All treatment modalities with surgery, radiation therapy and systemic cytostatic application were carried out. Nevertheless, the patient developed twice a local recurrence. Then we started a high-dose Beta-Interferon treatment. Until today a total disease-free survival is established.

Adult↗
PubMed1988

[Arterial regional chemotherapy of advanced breast cancer].

From October 1985 to November 1987, arterial regional chemotherapy with mitoxantrone was undertaken in 18 patients with primary far advanced carcinoma of the breast, of inflammatory or ulcerating type. Two patients had a bilateral carcinoma. Eight weeks after regional chemotherapy 18 of 20 tumours had become operable. Regression of tumour size by at least 50% (checked by mammography) was achieved in seven patients. Axillary lymphadenectomy gave negative results in 6 of 17 patients. Conversion of the receptor status occurred in only 2 of 12 patients. There were only few side effects: alopecia in 20%, leucopenia less than 2,500/microliters in 18%, thrombocytopenia less than 100,000/microliters in 7% patient. After a follow-up period of up to 28 months local recurrence was noted in two, distant metastases in three cases. A totally disease-free period was achieved in 14 patients.

Breast Neoplasms↗
PubMed1987

[HELLP syndrome: a life-threatening form of pre-eclampsia].

A rather unusual but dramatic form of EPH gestosis or pregnancy-induced hypertension is presented via the case of a 30-year old second gravida in the 30th week of pregnancy. This is a case of pre-eclampsia combined with haemolysis, elevated liver function tests and low platelet counts. Diagnostic features, pattern and pathophysiology are discussed with regard to international literature.

Adult↗