Biomedical subjects

R Parente

Publications and source records attributed to R Parente.

21 records · Page 2Linked to original sources

PubMed1981

[In vitro cytotoxicity in the immunological study of human glioblastomas].

An immunological study about the lymphocytes of nineteen patients affected by glioblastoma has been executed by using CML and ADCC tests. Eleven healthy subjects and nine ones affected by bladder carcinoma have been studied for control. The CML test has demonstrated an increase of citotoxic activity of lymphocytes in the totality of the patients affected by glioblastoma (37,09 +/- 3,67)% versus (4,00 +/- 1,78)% of controls. The ADCC test has demonstrated diminution of citotoxic activity of lymphocytes of the patients affected by glioblastoma in comparison with controls (20,57 +/- 9,77)% versus (29,18 +/- 6,67)% of the healthy controls versus (27,66 +/- 8,51)% of bearers of bladder carcinomas.

Adult↗

PubMed1980

Opening move in substance abuse therapy: appropriateness of treatment assignment.

This study examines the relationships between pretreatment severity of six problem areas commonly affected by addiction and type of discharge from inpatient substance abuse treatment. Subjects were 531 male veterans from five different inpatient substance abuse programs at the Veterans Administration Hospital, Coatesville, Pennsylvania. A comparison of patients in the five programs showed different patterns of problem severity, and different variables emerged as correlates or discriminators of discharge status. Results of multiple discriminant analyses were useful in predicting those patients who received an unfavorable discharge from treatment, although the analyses were not as successful in identifying those patients who received favorable discharges. Based on this data, some approaches to improving the match between patients and programs are discussed.

Adult↗

PubMedDate not supplied

Lymphocyte hyporesponsiveness during edema, proteinuria and hypertension (EPH) gestosis.

In vitro immunological tests showed that patients with pre-eclampsia are characterized by a greater degree of lymphocyte hyporesponsiveness to mitogens during pregnancy than normotensive controls. Thus, a relationship has been hypothesized between the hypoimmune lymphocyte response and the pathogenesis of the disease. We studied 20 non-pregnant healthy volunteers (group a), 11 women with a normal pregnancy (group b) and 13 women with EPH gestosis (group c). In all patients we determined the number of lymphocytes and the lymphocyte function (PHA, Con A, PWM responsiveness) in autologous and homologous plasma during pregnancy and 5 to 30 days after delivery. The mean values of the number of EAC and E rosettes in the three groups studied were similar. The mean values of the mitogenic response to PHA in autologous plasma were significantly reduced in both groups b and c in comparison with group a, but there was no statistical difference between groups b and c. The PHA lymphocyte responsiveness returned to normal in both homologous and autologous plasma after delivery. Our data demonstrate that no difference exists between pregnant women with and without pre-eclampsia as regards impaired cell-mediated lymphocyte response in vitro. Moreover, the diminished lymphocyte responsiveness to mitogens during pregnancy seems to be due to humoral circulating factor(s).

Adult↗