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Biomedical subjects

R Parslew

Publications and source records attributed to R Parslew.

10 recordsLinked to original sources
PubMed1997

An investigation into the effect of ischaemia and pressure on irritant inflammation.

Reports of chemical burns beneath tourniquets during orthopaedic procedures led us to explore the irritant effects produced by the skin antiseptics used during such procedures. A sphygmomanometer and tourniquet, at a pressure of 200 mmHg for 30 min, was used to created pressure and ischaemia which were then examined separately for their respective effects on irritant inflammation in normal subjects and those with atopic eczema. As no inflammation could be demonstrated with the antiseptics, we subsequently used the known irritant chemical anthralin to examine the effect of ischaemia with and without pressure. Site-related variation in anthralin-induced inflammation was observed but there was no demonstrable effect of either pressure or ischaemia on the inflammatory response. Therefore, as we are unable to show a relationship between ischaemia with or without pressure and irritant inflammation, we conclude that burns under tourniquets are likely to be idiosyncratic reactions and their further investigation requires examination of the individuals affected.

Anthralin↗
PubMed1997

Kaposi's sarcoma associated with immunosuppression for bullous pemphigoid.

Kaposi's sarcoma may occur in transplant recipients on immunosuppressive regimens, but is not well recognized in association with treatment for dermatological disease. We report two cases where multifocal Kaposi's sarcoma developed following iatrogenic immunosuppression with prednisolone and azathioprine for bullous pemphigoid. Both patients were HIV negative and, in one case, lesions regressed both clinically and histologically when immunosuppressive therapy was withdrawn.

Aged↗
PubMed1995

Partial lentiginosis.

A 14-year-old girl with partial unilateral lentiginosis affecting the left side of the neck, left shoulder and left upper arm is described. She also had a further patch of multiple lentigines over the right side of the face.

Adolescent↗
PubMed1994

Kaposi's varicelliform eruption due to herpes simplex in Darier's disease.

A young woman with Darier's disease treated with acitretin developed Kaposi's varicelliform eruption, from which herpes simplex virus was isolated. Herpes simplex infection complicating Darier's disease is well recognized but uncommon. A young woman of 19 years is described who presented with fever and general malaise.

Adult↗