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Biomedical subjects

R Pasic

Publications and source records attributed to R Pasic.

10 recordsLinked to original sources
PubMed2001

The clinical utility of a vaginal template designed to standardize suture placement during retropubic colposuspensions.

Suture placement and bite size utilizing a vaginal template are compared to a traditional surgical approach during modified retropubic colposuspension on four fresh-frozen human female cadavers. Overall, a larger suture bite was obtained utilizing the template (71.5 +/- 4.6 vs 46.7 +/- 25.3 mm2, P = 0.001). However, with increased surgical experience the suture bites obtained with the traditional approach and template technique were similar. Inconsistent suture placement relative to the urethrovesical junction and urethra was observed with both techniques. Differences in pelvic floor anatomy make consistent suture placement with respect to the urethrovesical junction and urethra neither possible nor entirely preferable with either technique. There seems to be little clinical value in the use of this vaginal template during modified retropubic colposuspensions.

Cadaver↗
PubMed1999

Laparoscopy in morbidly obese patients.

STUDY OBJECTIVE: To assess the safety and efficacy of different insufflation methods in morbidly obese women undergoing laparoscopy. DESIGN: Retrospective analysis of 13 years' experience (Canadian Task Force classification II-2). SETTING: University-affiliated hospital. PATIENTS: One hundred thirty-eight morbidly obese women (weight >250 lbs, body mass index >36). The heaviest patient weighed 400 lbs and had a body mass index of 66. INTERVENTION: Laparoscopic tubal sterilizations and diagnostic laparoscopies performed on an outpatient basis by residents under faculty supervision. MEASUREMENTS AND MAIN RESULTS: Of 138 patients, 36 underwent standard transumbilical insufflation with 5 failures, 83 had transuterine insufflation with 3 failures, 12 had subcostal insufflation with 1 failure, and 7 had open laparoscopy with 2 failures. CONCLUSION: The insufflation failure rate was significantly high for transumbilical insufflation and open laparoscopy, and not for transuterine or subcostal insufflation. Morbid obesity was not a contraindication to laparoscopy. (J Am Assoc Gynecol Laparosc 6(3):307-312, 1999)

Adult↗
PubMed1995

Laparoscopic suturing and ligation techniques.

The laparoscopic literature addressing operative techniques and use of suturing and knot tying is reviewed. Many operations that have traditionally been performed by laparotomy, may now be primarily accomplished by laparoscopy. Increasing improvements in laparoscopic instruments and techniques permit more surgical procedures to be performed on an ambulatory basis, therefore setting a new trend in gynecologic surgery. The evolution of endoscopic procedures will require laparoscopic surgeons to master suturing techniques which will improve their level of comfort and performance. This review of suturing and knot tying procedures may be helpful to both the established surgeons and the beginners as it gives a comprehensive review of laparoscopic suturing and knot tying techniques.

Equipment Design↗
PubMed1990

Comparison of sex steroid receptor determinations in human breast cancer by enzyme immunoassay and radioligand binding.

Most investigators comparing ligand-binding procedures for quantifying estrogen and progestin receptors in human breast cancer with procedures employing monoclonal antibody-based methods have utilized an inappropriate variety of reaction conditions, including the elimination of sodium molybdate in the steroid-binding assays. We studied 197 biopsies of human breast cancer, comparing the results of simultaneous measurements of both estrogen and progestin receptors in identical cytosols by enzyme immunoassay and by radioligand binding using the commercially available kits developed by Abbott Laboratories and by DuPont/NEN Products, respectively. Regression analyses comparing the results from the two procedures indicated a linear relationship, with correlation coefficients ranging from 0.79 to 0.93 for both types of receptors over a wide range of data. Using the widely established cutoff value of 10 fmol/mg of cytosol protein for the ligand-binding method, and calculating sensitivity and specificity limits according to McNeil et al. (1975), an equivalent cutoff value of 15 fmol/mg of cytosol protein was determined for the enzyme immunoassay of these receptors. Endocrine status of the patient did not appear to alter the cutoff values of either estrogen or progestin receptors when determined by enzyme immunoassay. We recommend that these cutoff values be considered until the results of clinical correlations are completed.

Breast Neoplasms↗
PubMed1990

Transuterine insertion of Veress needle in laparoscopy.

A pneumoperitoneum separating the anterior abdominal wall from the intraperitoneal organs is essential to view the pelvic organs and to perform laparoscopic surgery. A Veress needle was inserted through the uterine fundus to establish a pneumoperitoneum in 100 women undergoing laparoscopy for sterilization or diagnostic purposes. The transuterine approach was chosen for 86 women because of obesity and for 14 because a previous abdominal insertion had been unsuccessful. There were no complications associated with the transuterine Veress needle placement. This method should be considered for obese patients and for those women in whom the transabdominal approach is unsuccessful.

Female↗
PubMed1989

Influence of O.C.T. embedding compound on determinations of estrogen and progestin receptors in breast cancer.

Estrogen receptor (ER) and progestin receptor (PR) concentrations in tumor biopsies are important predictive indicators of a clinical response to endocrine therapy of breast cancer. To assess interference of O.C.T. (optimum cutting temperature) embedding compound in assays of ER and PR by radioligand binding, we determined specific binding capacities and affinities of ER and PR in cytosols by a multipoint titration method, using split samples of 14 breast-tumor biopsies, one portion serving as untreated control, the other treated with O.C.T. There was no statistically significant difference between these two groups. We then compared these data with those of historical controls analyzed both in the presence and absence of sodium molybdate (10 mmol/L). Eighty breast-tumor specimens (mean +/- SD patients' ages, 59 +/- 14 y) embedded in O.C.T. compound and analyzed without molybdate gave ER and PR values that differed insignificantly from those for 306 samples (patients' ages, 61 +/- 14 y) untreated with O.C.T. Thirty-nine specimens (patients' ages, 58 +/- 15 y) embedded in O.C.T. compound were analyzed in the presence of molybdate and compared with the results for 288 specimens (patients' ages, 61 +/- 14 y) untreated with O.C.T. Again, there was an insignificant difference in the concentrations and affinities of receptors in the two groups. Evidently O.C.T. compound does not alter the receptor status of tumor biopsies.

Aged↗