Biomedical subjects
Publications and source records attributed to R Pautrizel.
Biological effects of microwaves on experimental trypanosomiase in the Mouse depends on the state of development of the animal. In fact such stimulation needs a mature immune system. Nevertheless, the increasing of the molecular immune response is only one of the aspects of protection mechanisms stimulated by such microwaves.
The cure of Trypanosoma equiperdum infected Mice obtained after treatment with an association of electromagnetic waves and a magnetic field is probably linked with the immune state of the host. A severe depression of the immune system suppresses the ability of the animals to eliminate the parasites after physical stimulation.
The study of the evolution of Plasmodium berghei berghei is made in mice kept in a high temperature (35 degrees C) throughout the experiment. Some of these mouse parasites (less than 30%) show a gigantic atypical morphology. In the parasite growing in animals kept at 35 degrees C, the amount of DNA is higher than DNA rate of the parasites growing in control mice (20-22 degrees C). There is no evidence of any relation between the increase of DNA amount and the morphological modification of these parasites.
Swiss Mice infected with Plasmodium berghei berghei and maintained in permanence in a hot environmental temperature undergo a chronic infection whereas controls maintained at the laboratory temperature develop always an acute and lethal infection. The hot environmental temperature does not seem to have any action on the pathogenicity of the parasites. Host defences are stimulated.
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Different evolutions of experimental trypanosomiasis are observed in Mice kept in a permanent 35 degrees C environment. Evolution depends on the individuality or the strain of the host animal. An experimental factor influence on the host mechanism defense rather than on the parasite multiplication rate is shown.
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The remarkable efficiency of the physical treatment using such an association enables the mice to handle an infection otherwise lethal in a few days. The recovery is due to a very strong stimulation of defense system of the host-animal particularly those related to the immune responses. This effect can be obtained in spite of the depression of the immunological defenses prior to the infection. The control of the infection by the mice is not due to direct action of the radiation on trypanosomes.
The multiplication of the trypanosomes in a "diffusion chamber" is great during the first 4 or 5 days following implantation. The reduction in numbers of parasites on the following days depends largely on the humoral antibodies resulting from the immune response.
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