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Biomedical subjects

R Peltonen

Publications and source records attributed to R Peltonen.

13 recordsLinked to original sources
PubMed1992

An uncooked vegan diet shifts the profile of human fecal microflora: computerized analysis of direct stool sample gas-liquid chromatography profiles of bacterial cellular fatty acids.

The effect of an uncooked extreme vegan diet on fecal microflora was studied by direct stool sample gas-liquid chromatography (GLC) of bacterial cellular fatty acids and by quantitative bacterial culture by using classical microbiological techniques of isolation, identification, and enumeration of different bacterial species. Eighteen volunteers were divided randomly into two groups. The test group received an uncooked vegan diet for 1 month and a conventional diet of mixed Western type for the other month of the study. The control group consumed a conventional diet throughout the study period. Stool samples were collected. Bacterial cellular fatty acids were extracted directly from the stool samples and measured by GLC. Computerized analysis of the resulting fatty acid profiles was performed. Such a profile represents all bacterial cellular fatty acids in a sample and thus reflects its microflora and can be used to detect changes, differences, or similarities of bacterial flora between individual samples or sample groups. GLC profiles changed significantly in the test group after the induction and discontinuation of the vegan diet but not in the control group at any time, whereas quantitative bacterial culture did not detect any significant change in fecal bacteriology in either of the groups. The results suggest that an uncooked extreme vegan diet alters the fecal bacterial flora significantly when it is measured by direct stool sample GLC of bacterial fatty acids.

Adult↗
PubMed1978

The prevalence of chronic diseases in children in out-hospital care in Finland.

The records of public health nurses have been used for an estimate of the prevalence of children in domestic care and suffering from various kinds of chronic diseases. This estimate provided a basis for computation of the number of chronically ill children in out-hospital care in Finland. The research was carried out as a sample research and this inquiry resulted in the information of the anamnesis of 12,721 chronic children under 16 years of age taken care of at home. We have counted as chronics those children whose disease is lingering either due to its mechanism of origin or to its nature or known to be such from experience. The total prevalence was 53% of the child population in Finland which corresponds to 59,000 chronically sick children. The geographical distributions of the groups of the diseases were not quite alike in the different parts in our land. The greater prevalences were found on the other hand in Northern Finland and in the wide archipelago of Southwestern Finland. The most common types of the chronic diseases of children were found to be those of sense organs (the total prevalence was 18%). The prevalence of allergic diseases varies between 6--12% and the disease group of endocrinic glands 1.0--3.4%. The prevalence of the neurological diseases was 2.3% and the biggest group consists of the convulsive. The prevalence of the other groups of diseases were: the psychiatric diseases 2.2%, the urological diseases 1.4% and the hematological diseases 0.8%.

Adolescent↗
PubMed1976

Immediate information expected by the neonatologist from the placenta.

As the obstetrician attends to the mother and the pediatrician to the child, the placenta often tends to be ignored. Nevertheless, essential anamnestic information about the condition of a newborn infant, and especially of a premature, can be gained from careful scrutiny of the placenta and fetal membranes. This paper emphasizes the importance of gross examination of the placenta and membranes as a source of immediate information to the pediatrician within the delivery room.

Abruptio Placentae↗
PubMed1975

Antibodies to herpesvirus hominis types 1 and 2 among women with neoplastic change of uterine cervix.

The occurrence of antibodies to herpesvirus hominis types 1 and 2 was studied in Finland among patients with a neoplastic change of the uterine cervix. The following groups were studied: 220 patients with malignant or premalignant lesions of the uterine cervix, 143 control patients matched for age, socioeconomic level, marital status, home district and number of deliveries and 82 patients with breast or stomach cancer. Antibodies to HVH types 1 and 2 were determined using the neutralization test. Sera showing an index of less than or equal to 100 were accepted as positive to type 1 and those of greater than or equal to 85 as positive to type 2. Among patients with a neoplastic change of the uterine cervix the frequency of type 1 antibodies varied between 70% and 79%. In the control group the frequency was 84% and among patients with some other malignancy 91%. These differences in the frequencies of type 1 antibody were not statistically significant. Type 2 antibodies were present in 35 to 47% among dysplasia and malignancy of the cervix. In the control group it was 18% and in other malignancies 20%. The differences between these groups and the controls were almost significant, significant and highly significant, respectively. Differences could also be observed in the distribution of neutralization indexes. The average index calculated from all sera was 48 both in the control group and in the group of other malignancies, while in sera of patients with dysplasia, carcinoma in situ and invasive carcinoma the respective vlaues were 70, 66 and 79. The results are discussed in terms of the role of herpesvirus hominis type 2 in the development of cervical cancer.

Adult↗
PubMed1975

Disappearance of tracheobronchial fluid at birth in the lamb.

Bronchography was performed in lambs before, during and after the first breath. Swallowing of the contrast medium containing tracheobronchial fluid was observed before the first breath. Intratracheal pressure changes ranging up to 20 mmHg were observed during respiratory movements which did not open the alveoli. The lamb did not start breathing as long as the snout was covered although there was a direct connection between the trachea and atmospheric air through a tracheostomy. When the snout was uncovered a lamb in good condition drew its first breath and the spreading of the contrast material into the peripheral parts of the lungs was almost explosive. The diameter of the tracheobronchial tree widened as a result of the initiation of respiration. It is suggested that both swallowing in the pharynx and absorption into the blood circulation below the larynx play an essential role in the disappearance of the tracheobronchial fluid. Intrauterine aspiration seems less probable in the light of these observations.

Animals↗