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Biomedical subjects

R Persson

Publications and source records attributed to R Persson.

35 records · Page 2Linked to original sources
PubMed1981

5-HT reuptake inhibitors plus tryptophan in endogenous depression.

In a previous double-blind, 3-week study we compared the effect of clomipramine + placebo with clomipramine + tryptophan in 24 patients with endogenous depression. The patients in the latter group showed a significantly more rapid improvement than those in the former group, especially with regard to the depression-anxiety cluster of symptoms. These results prompted us to perform a similar study in which zimelidine, a more specific inhibitor of 5-HT reuptake, was used instead of clomipramine. In other respects the design was practically identical to that used in the previous study. Unexpectedly, tryptophan in combination with zimelidine, was not superior to placebo + zimelidine with respect to antidepressant activity. In comparison with the previous study, the antidepressant action of zimelidine showed no statistically significant difference from clomipramine. However, the patients tended to show a more prompt response after zimelidine + placebo than after clomipramine + placebo. The changes in CSF metabolites were likewise different in the two studies. In the two studies taken together 12 out of 49 patients showed prompt improvement within one week. This raises the question whether the therapeutic response to antidepressant drugs necessarily involves a delay as is generally assumed. Side effects were remarkably few and mild in the second study.

Biogenic Amines↗
PubMed1981

Assessment of tooth mobility using small loads. III. Effect of periodontal treatment including a gingivectomy procedure.

The effect on tooth mobility of periodontal treatment utilizing a gingivectomy procedure was studied during a period of 26 weeks in 25 maxillary anterior teeth of six subjects with moderate to advanced periodontal disease. The gingival conditions were evaluated by gingival fluid measurement and the loss of marginal bone as seen on radiographs. Tooth mobility was measured in a bucco-lingual direction using forces between 20 p and 80 p. The results show a decrease of gingival fluid throughout the study. Tooth mobility was already reduced in the majority of teeth 2 weeks after surgery. An average reduction of tooth mobility amounting to 43.7% (using the corrective formula of Mühlemann 1960) was observed after 4 weeks. No additional reduction took place during the remaining experimental period.

Adult↗
PubMed1981

Assessment of tooth mobility using small loads. IV. The effect of periodontal treatment including gingivectomy and flap procedures.

Tooth mobility at loads below 100 p, gingival fluid amounts and bone score heights were studied in five subjects. In all 28 maxillary anterior teeth were investigated during a period of 68 weeks. In order to enlarge upon a previous investigation of tooth mobility following periodontal surgery (Persson 1980), the effects on tooth mobility of gingivectomy and flap procedures were compared. A split-mouth technique was used for the two surgical procedures which were performed during one session. No preoperative differences of the investigated parameters were found. During the first weeks after surgery, an increase of tooth mobility was seen which amounted to +80% maximum (flap side) and +13.1% (gingivectomy side). The final tooth mobility changes were -60% on the flap side and -40% on the gingivectomy side. No significant differences of tooth mobility were found between the two surgical methods. The present findings of tooth mobility following surgery also indicated a considerable time lapse before any major decrease of tooth mobility took place.

Adult↗
PubMed1980

Assessment of tooth mobility using small loads. I. Technical devices and calculations of tooth mobility in periodontal health and disease.

An apparatus for recording tooth mobility of maxillary anterior teeth using loads below 100 p in a bucco-lingual direction is described. Strain gauges and a differential transformer are used as sensors of force and displacement. The displacement is recorded at the same location on the tooth surface and in the same direction as the loading force. Compressed air is used as the source of force. Documentation of signals is obtained by means of a two-channel potentiometric recorder. Tooth mobility was studied in six subjects with healthy periodontal conditions and in six subjects with moderate periodontal disease. Repeated measurements under standardized conditions demonstrated a satisfactory reproducibility of the measuring method. Tooth mobility curves within the 20-80 p loading range were transformed to lines of regression. Analysis of such lines seems to provide further information of tooth mobility qualities as compared to previous methods of tooth mobility measurements.

Dental Stress Analysis↗
PubMed1980

Assessment of tooth mobility using small loads. II. Effect of oral hygiene procedures.

Tooth mobility at loads between 20 p and 80 p was studied in maxillary incisors and canines in eight subjects with moderate periodontal disease. The periodontal conditions of the investigated teeth exhibited clinical criteria of gingival inflammation and a moderate loss of attachment. None of the subjects showed subjective or clinical signs of occlusal disturbances. In all, 35 teeth were investigated over the 12-week period following periodontal hygiene treatment, including oral hygiene instructions and removal of supra- and subgingival plaque and calculus. During the course of the investigation, a gradual decrease of tooth mobility was observed amounting to a tooth mobility decrease of 65% (using the corrective formula described by Mühlemann 1960) at 50 p load. Tooth mobility curves within the 20--80 p loading area were transformed to lines of regression (Persson & Svensson 1980). Analyses of the lines showed significantly lower tooth mobility values 12 weeks after start of treatment.

Adult↗
PubMed1979

On the relation between peripheral atherosclerosis and serum lipoproteins.

The occurrence and degree of peripheral atherosclerosis in 30 male patients with symptoms of intermittent claudication were studied by arteriography. The changes observed in the angiograms were codified. In all patients the concentrations of triglycerides and cholesterol were determined in whole serum and in the three major lipoprotein classes--very low density, low density and high density lipoproteins. These data were compared with those of a control material and were also correlated to the codified angiographic findings in each individual patient. Positive significant correlation was not found between the arteriographic changes and the serum concentrations of lipids and lipoproteins, which might be explained by an advanced stage of the disease where such relationships might not appear.

Adult↗
PubMedDate not supplied

Radiology in the Nordic Countries.

NEMT, Nordic Evaluation of Medical Technology, conducted a study in 1988-89 on the use and diffusion of diagnostic radiology technologies in Denmark, Finland, Iceland, Norway and Sweden, i.e. the Nordic Countries. The study analysed the responses to a questionnaire sent to all Nordic radiology departments. Our findings show a variation from about 500 to nearly 900 radiology examinations per 1000 inhabitants among the Nordic Countries. Some of the differences are explained by unique structural factors of the health care system in each country, even if they all provide comparable public health services. Other differences are explained by variations in medical practice, accessibility to new imaging modalities, and replacement policies. This paper summarizes the results of the study.

Diffusion of Innovation↗
PubMedDate not supplied

Dietary and salivary factors associated with root caries.

In this pilot study, dietary habits, microbial factors, and salivary factors in 20 older adults who had active decay on root surfaces were compared with those of 20 adults who had inactive or no root caries. In this case-control study, the groups were matched by sex and were of similar age. Subjects using medications known to induce dry mouth were excluded. Subjects completed a nutrition interview and a four-day food diary. Stimulated whole saliva flow rate, buffering capacity, levels of salivary lactobacilli with use of the Dentocult method, and S. mutans cultured on MSB agar were determined. The root caries group had a greater mean number of eating occasions per day (6.1 vs. 4.6), more frequent exposures to fermentable carbohydrates (5.8 vs. 4.2), and higher average daily sugars intake (133 g/day vs. 105 g/day) than the control group. Root caries subjects had significantly higher lactobacilli counts and less salivary buffering capacity. Within the root caries group, significant correlations were found with Root Caries Index and lactobacilli (r = 0.56) and S. mutans counts (rs = 0.50). These results show that frequent intake of simple sugars, high lactobacilli counts, and low saliva buffering capacity may be risk factors associated with root caries in older adults.

Aged↗