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Biomedical subjects

R Peyser

Publications and source records attributed to R Peyser.

6 recordsLinked to original sources

Vaginal ulcerations due to lithium carbonate therapy.

A twenty-nine-year-old woman who had been taking lithium carbonate for seven years experienced ulcerated lesions of the vaginal mucosa and acneiform eruption on both thighs. Histopathologic appearance of the skin biopsy specimens was consistent with lichenoid cutaneous changes. The cutaneous lesions cleared when use of the drug was discontinued.

Acne Vulgaris↗

The establishment of an ovum donation program using a simple fixed-dose estrogen-progesterone replacement regimen.

Most ovum donation (OD) programs involve cycle synchronization between recipient and donor for normally cycling recipients and a complex estrogen-progesterone replacement regimen for recipients with ovarian failure. In 1987, Serhal and Craft (1) suggested the use of a fixed-dose estrogen-progesterone regimen for recipients who were normally ovulatory and to those with ovarian failure. Following this protocol, and simplifying it still, the authors administered 6 mg estradiol valerate (E2) daily orally starting on day 2-6 of induced withdrawal bleeding, augmented with 100 mg progesterone in ethyl oleate (P) intramuscularly daily, starting any time between 4 days prior to and the day of oocyte pickup. All recipients underwent embryo transfer at a 2-pronuclei (2PN)-10-cell stage. A group of 21 patients underwent 26 treatment cycles, resulting in 16 pregnancies. Twelve of the patients gave birth, one to triplets, two to twins, and nine to singletons. Four patients miscarried in the first trimester of pregnancy.

Adult↗

Hypotensive effect of bromocriptine in normal eyes.

The effect of a single oral dose of 2.5 mg Bromocriptine on intraocular pressure over a 12 hour period in a group of 20 puerperal women with normal eyes, is reported. Intraocular pressure was significantly reduced, the maximal response being 3-4 hours after administration. Possible explanations for the reducing effect of Bromocriptine on intraocular pressure are discussed.

Administration, Oral↗

Diffuse unilateral subacute neuroretinitis.

In December 1980, a 26-year-old black man came to the Washington Hospital Center Eye Clinic with a unilateral decrease in visual acuity, vitreous inflammation, optic disk pallor, and a degenerated retinal pigment epithelium. A motile subretinal worm was subsequently found. Unlike an earlier series of 18 patients with diffuse unilateral subacute neuroretinitis reported by other authors, this patient exhibited eosinophilia and a highly positive ELISA for Toxocara.

Adult↗

Light intensity and visual acuity following cataract surgery.

The authors analyzed 310 cataract operations that were randomly distributed between two operating rooms, each containing a microscope with different light intensities. The light intensity of one microscope was almost threefold greater than the other. One hundred seventy-seven patients were excluded from this study because of medical or ocular problems that might affect visual acuity. The remaining 133 patients are the subjects of this paper. Seventy-one were operated upon under high intensity light, and 62 were subjected to lower illumination in the operating room. Visual acuity after operation was correlated with type of microscope, age, sex, method of cataract extraction, and use of intraocular lenses. Reduced visual acuity (20/40 or worse) was consistently more common with high intensity light and with increasing age. Further investigation is recommended to establish the cause of this reduced acuity.

Age Factors↗