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Biomedical subjects

R Pfister

Publications and source records attributed to R Pfister.

At least 91 records · Page 5Linked to original sources
PubMed1982

Complement-dependent lymphocytotoxic antibodies (CLA) in systemic lupus erythematosus preferentially inhibit the generation of alloreactive cytotoxic T cells in secondary CML.

Complement-dependent lymphocytotoxic autoantibodies (CLA) are invariably present in sera of patients with active systemic lupus erythematosus (SLE). This study aimed to test for the influence of such antibodies on the in vitro generation of human alloantigen reactive proliferative and cytotoxic T cell responses. Unsensitized or alloantigen primed memory cells were pre-treated with CLA in the presence or absence of complement. Following stimulation of the remaining cells with allogeneic peripheral blood mononuclears, the proliferative and cytotoxic capacity was evaluated. Results indicated that only pre-treatment with CLA and complement influenced these reactions whereas in the absence of complement antibodies were totally ineffective. Pre-treatment of unsensitized precursor cells reduced and delayed both proliferative and cytotoxic reactivity; in contrast, pre-treatment of memory cells exclusively reduced cellular cytotoxicity. It thus appears that such SLE associated autoantibodies in the presence of complement are capable of modifying the balance between different subsets of alloreactive T cells.

Autoantibodies↗
PubMed1981

[Problems in the treatment and after care of chronic dermatoses. A clinical study on hametum ointment].

Two groups of patients with endogenous eczema (n = 36) and toxic degenerative eczema (n = 80) were treated with Hametum Salbe and a control preparation. The present results indicate that Hametum Salbe is superior in effectiveness in treatment of atopic dermatitis compared to the control preparation. There was no difference in therapeutical effectiveness in the treatment of primary irritant contact dermatitis. For treatment and interval therapy as well as for long-term treatment of chronic dermatoses Hametum Salbe is a valuable dermatological preparation which can be used without any risk in long-term therapy.

Adolescent↗
PubMed1980

Collagen heterogeneity in normal rabbit cornea. I. Isolation and biochemical characterization of the genetically-distinct collagens.

Limited proteolysis of preparations of mature rabbit cornea with pepsin allows the recovery of approximately 90% of the tissue collagen in soluble form. Using recently described selective precipitation techniques, the soluble cornea collagen can be resolved into two major fractions. The predominant fraction, which accounts for about 95% of the solubilized collagen, was identified by means of solubility properties, electrophoretic and chromatographic properties, as well as amino acid analyses of its constituent chains, as Type I collagen. The alternate fraction, which accounts for virtually all of the remainder of the solubilized cornea collagen, was identified by means of the same criteria as collagen comprised of the A and B chains. In addition, the stoichiometry of the latter chains in preparations of cornea collagen indicate that in the cornea these chains are likely to participate in the formation of only one type of collagen molecule with the chain composition, AB2. And finally, the demonstration that Type I and the AB2 collagens are the predominant forms of collagen recoverable from the mature cornea strongly suggests that molecules comprised of the A and B chains are not necessarily confined to basement membrane structures.

Amino Acids↗
PubMed1977

[Malignant tumors of the nails].

The clinical symptoms of malignant neoplasms (M. Bowen, Carcinoma spinocellular, malignant melanoma) in the area of the finger- and toe-nals are described. Because of the poor prognosis of these neoplasms in this area early detection and treatment is of utmost importance

Bowen's Disease↗
PubMed1977

[Are sandflea infections increasing?].

A report on two cases is given. The patients showed the typical skin affections after trips to Africa. Tungiasis occasionally leads to secondary infections and may be the cause of longterm inflammation or erysipelas. Treatment is discussed and a possible increase of tungiasis because of an increase of tourists to tropical countries is pointed out.

Adult↗