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Biomedical subjects

R Piñero

Publications and source records attributed to R Piñero.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Non ulcer dyspepsia, endoscopic gastritis and Helicobacter pylori].

We studied 33 patients with non ulcer dyspepsia and endoscopic gastritis. 21 were female (63.4%) and 12 male (36.4%). Helicobacter pylori (HP) was investigated by gastric mucosal biopsy. Urease test, Gram, culture, and histology were performed in all and two or more of these test hat to be positive to consider HP infection. 16/33 resulted HP positive (48.8%). Erosive gastritis was most commonly associated with H.P. infection (62.5%). This was statistically significant. In all the cases HP positive chronic gastritis was present. 15/16 were active chronic gastritis. Our results suggest that erosive gastritis is most frequently associated with HP infection and non ulcer dyspepsia.

Adolescent↗
PubMedDate not supplied

[Nonulcerative dyspepsia associated with Helicobacter pylori].

30 patients with non ulcer dyspepsia (NUD) were evaluated to find out if there was a relationship with Helicobacter pylori (HP) infection. Gastric biopsies from the antrum were taken and two of them sent to pathology to be stained with H&E and Warthin-Starry. The other three were sent to Microbiology, for urease-test, culture and frotis with Gram stain. To diagnose HP was necessary to get it at least in two of the performed test. This was possible in 20 (66.66%). Chronic active gastritis was observed in 15/20 (75%) and in the 3/10 HP negative patients none had histological alteration shown. Normal aspect of gastric mucosa did not predict Helicobacter pylori infection. The presence of the bacteria could not be correlated to any kind of symptoms and always was associated with chronic gastritis.

Adolescent↗
PubMedDate not supplied

[The recurrence of duodenal ulcer after treatment for Helicobacter pylori. A randomized, double-blind, placebo-controlled study].

We studied 63 duodenal ulcer (DU) patients (p) diagnosed by upper gastrointestinal endoscopy (UGE) and Helicobacter pylori positive (HP). Patients were randomized, double-blinded to receive placebo (PG) 30p or Amoxicillin plus Metronidazole 33p (TG). All of them took Famotidine for six weeks and at this point UGE was performed. DU healing was similar in both groups. HP eradication was possible in 14/24p of TG and 4/23 of PG (58.33% vs 17.39%) difference was statistically significant. DU recurrence at 3 months was 68.75% in PG vs 11.76% in TG (p = 0.001). At the end point of the study global recurrence of DU was 3/24p in TG vs 19/23 in PG (p = 0.000001). Our findings suggest that DU recurrence is related to the presence of HP. Definitive treatment to permanently eradicate the bacteria is to be evaluated.

Adolescent↗
PubMedDate not supplied

[Barrett esophagus. Frequency, endoscopic, histologic, and clinical characteristics].

We reviewed 9210 upper gastrointestinal endoscopic examinations during a 66 month period and found 23 (0.24%) diagnosis of Barrett's Esophagus (BE). Male/female ratio was 1.3:1. Age was 23-79 year old (y/o) mean 50.60 y/o. Histological diagnosis was confirmed in 23/35 cases and cardiac type was present on 60.86%, intestinal type in 39.10%. Dysplasia was not found. Endoscopic mucosal lesions were: finger-like projections 13/23 (56.52%), ulcers in five cases (21.73%), islands of columnar epithelium and circumferential extension in 2 each (8.69%), and stenosis in one (4.34%). The low frequency in this series could be attributed to a retrospective analysis. The high risk for developing adenocarcinoma of the esophagus justifies prospectives trials in our country to verify the prevalence.

Adult↗
PubMedDate not supplied

[Percutaneous liver biopsy in outpatients].

We studied prospectively 44 patients with diffuse liver disease. We performed percutaneous liver biopsy in these outpatients. They were required to be in absolute response during the following 4-6 hours after the biopsy was completed. After that period, they could go home and have a relative rest for the remnant day. These patients were followed by clinical evaluation and by real time abdominal ultrasound. We found some complications: Transitory arterial hypotension, pain in the site of puncture, hepatic hematomas. Only one of the patients with hematomas required hospitalization during 24 hours. The mortality was 0%. According to our experience, the hepatic biopsy is a procedure that can be performed in outpatients with a wide margin of security. An important point of view to consider is the economic advantage since it means a decrease in costs by each hepatic biopsy accomplished considering the cost/day of hospitalization.

Adolescent↗
PubMedDate not supplied

[The urease test for the diagnosis of Campylobacter pylori infection].

To evaluate the usefulness of urea media routinely applied in the diagnosis of Campylobacter pylori infection, 50 patients with gastroduodenal pathology were studied. Two biopsies of antral mucosa were taken; one of them was placed on Urea Agar Base (Difco) prepared without agar, and the other in saline for Gram staining and culture in selective and enriched media. In 39 patients Campylobacter pylori was found by Gram staining and/or culture. 38 of them were urease test positive, 24 (61.5%) during the first hour, 8 (20.5%) between the first and fourth hours and 6 (15.3%) between 4 and 24 hours. The sensitivity of the test increased from 61.5% at the first hour to 82.0% and 97.3% at 4 and 24 hours, respectively. The specificity was 100% for all the readings. We believe that the urease test with medium of Urea Agar Base is useful for the diagnosis of Campylobacter pylori infection. However, we recommend the selection of two or three combined methods for better confirmation of the infection.

Culture Media↗
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[Frequency of Campylobacter pylori in apparently healthy and asymptomatic Venezuelans].

We evaluated 21 healthy asymptomatic Venezuelan volunteers free of risk factors for gastritis with upper gastrointestinal endoscopy, and four antral biopsies: a)2 for histological examinations, b) Urease test, c) culture and gram coloration. 13 out of 21 subjects were positive for Campylobacter pylori (61.30%) all of them had chronic gastritis and in the negative cases 7 were considered histologically normal. Urease test was positive in 12/13 with a sensitivity of 92% and 100% specificity. Frequency in our series is high for Campylobacter pylori (61.30%) and this justify prospective and massive study of the population to detect de prevalence in our country with simpler and cheaper methods.

Adult↗
PubMedDate not supplied

[Portal hypertensive gastropathy: histologic and endoscopic correlation].

Portal Hypertensive Gastropathy (PHG) diagnosed in 42 patients by upper gastrointestinal endoscopy and was correlated with histological findings of gastric biopsies taken from fundus-body and antrum and observed blinded by the pathologist. We found that in the fundus PHG was observed in 97.14% and of these 77.14% were mosaic pattern. Submucosal vessel dilatation was observed in 65.71%, congestion in 60% and chronic gastritis in 62.85%. Histologic and endoscopic correlation was possible in 85.71%. Our results show a histologic and endoscopic correlation.

Adolescent↗
PubMedDate not supplied

[Splenic abscess, a diagnostic and therapeutic problem].

Splenic abscess remains a rare entity, reserved for patients with predisposing factors or immunosuppressive conditions. In our 13 patients in which a splenic abscess was diagnosed pre- or intra-operatively, an average of 14 days past before the diagnosis was made. Main symptoms were fever, upper left abdominal pain, auscultatory left basal anomalies and splenomegaly. Culture from the spleen material included E. coli, Staphylococcus, Proteus, Salmonella and Streptococcus v. Although splenectomy has been considered the standard procedure for this pathology, we treated our last three patients by means of Computed Tomography Percutaneous Drainage (C.T.G.P.D.). There was no need for splenectomy after this procedure and there were no complications associated with the C. T. G. P. D.

Abscess↗
PubMedDate not supplied

[Gastric mucosa injuries in portal hypertension].

Portal Hypertension (PH) was diagnosed in 114/4145 patients (p) evaluated by upper gastrointestinal endoscopy during 1991-92 (2.75%). Portal hypertensive gastropathy (PHG) was found in 39.47% p. Mild PHG was observed in 82.22% and esophageal varices grade was directly correlated to PHG presence. This is a new entity to be considered because of its bleeding possibility in PH patients.

Adolescent↗