A study has been carried out in 690 patients admitted in a Paris hospital and from Mali, Senegal and Mauretania origin, in order to compare the three available techniques for the diagnosis of infection with S. haematobium: urine centrifugation deposit control, biopsy of rectal mucosa and indirect immunofluorescence test. The prognostic value of each of these three techniques has been reevaluated. (Formula: see text), Living eggs have been detected in 55 p. 100 of the patients by direct examinations and a prevalence of 75 p. 100 has been computaned for S. haematobium.

Fluorescent Antibody Technique↗

PubMedDate not supplied

[Oltipraz as brief treatment of schistosomiasis (comparison with niridazole) (author's transl)].

161 patients affected by schistosomiasis due in most cases to S. haematobium, and less frequently to S. mansoni, received one day treatment with 4,5 g a day of oltipraz in a first group and, later on, 3 g a day in another group. A control after one year was possible for patients having received 4,5 g one day dosis. Urin control, rectal mucosa biopsy (R.M.B.) and indirect immunofluorescence test (I.I.F.) were performed in patients who did not return to infested areas during that period of time; in almost all cases, the urin control was negative; in 52 p. 100 of the cases the R.M.B. shown no live egg and I.I.F. test was significantly decreased with individual variations. -- These results are compared to those of a previous and similar study on the effects of niridazole. -- Side-effects, mostly digestive or nervous, are frequent with a 4,5 g dose and less frequent with 3 g. They rarely compel to discard the treatment and they never persist after the morning following the treatment is stopped. There is no electrocardiographic change. -- Doses below 3 g in one-day intake are presently studied in order to fix the minimal acting dosis.

Adolescent↗

PubMedDate not supplied

[A new case of Plasmodium falciparum malaria resistance to chloroquine in Africa (Rwanda) (author's transl)].

Report of a case of P. falciparum malaria observed in Rwanda. Relapse and positive blood thick smear has been observed 8 days after the beginning of the treatment of the previous fit of fever by chloroquine. Authors recall the resistance criteria fixed by O.M.S. for antimalarial drugs and question wether drug-resistant malaria is not spreading in East-Africa, considering some similar cases reported in the region.

Chloroquine↗

PubMedDate not supplied

[Pulmonary complications of drepanocytemia: recent advances (author's transl)].

Pulmonary complications are non very frequent in drepanocytemia (3 to 7 p. 100) but they are often severe and sometimes dramatic. They happen in the homozygotic forms or in the double heterozygotic ones (SC and Sbeta Tahal). Infections, most often due to pneumococcus, are specially frequent in children, though infractions are generally observed in youth and grown-ups. All these patients suffer of an impairement of their respiratory function and of their immunological capacity.

Acute Disease↗

PubMedDate not supplied

[Comparative value of parasitological investigations and immunological reactions in the post-therapeutic surveillance of chronic urinary schistosomiasis].

A comparative evaluation of parasitological (in urine and R. M. B.) and immunological (IgE and I. F. I.) investigations in the post-therapeutical course of the urinary schistosomiasis was carried out in a group of 25 patients treated with niridazole and on a group of 25 patients treated with 35 972 RP. The recovery must be based on both the disparition of eggs simultaneously in urine and R. M. B., the former is not sufficient because eggs could be found in R. M. B. when absent in urine. IgE and I. F. I. reaction gave conflictual data in the evaluation of the treatment.

Humans↗