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Biomedical subjects

R Pirani

Publications and source records attributed to R Pirani.

6 recordsLinked to original sources
PubMed1979

[Short-term and median-term effects of tienilic acid in hypertension].

Fifty nine patients suffering from slight or moderate essential arterial hypertension underwent hypotensive treatment. After one week of wash-out, therapeutic administration of tienilic acid in doses of 500 mg per day was begun; in the third week we combined a non diuretic hypotensive drug (prazosin, propranolol, alfametil-dopa). At the beginning of the study all patients underwent an ECG, a clinical cardiological examiniation, funduscopy examination, funduscopy examination, a heart X - ray in 3 standard positions and a routine blood test which was repeated during and at the end of the treatment. The patients' blood pressure taken in an upright and supine position, showed statistically significant reductions for both systolic and diastolic values in all 3 groups, whereas the routine blood tests gave evidence of a marked reduction in the uriacid, triglycerides and potassium levels. In order to correct the latter we had to administer high oral doses of potassium, and in one case admittance to hospital was necessary since the potassium level was lower then 2.5 mEq/l.

Adult↗
PubMed1979

[Hemodynamic observations in a group of hypertensive patients treated with tienilic acid (author's transl)].

In ten patients suffering from slight or moderate essential arterial hypertension, undergoing treatment with tienilic acid at 500 mg per day, various hemodynamic parameters were assessed by means of ecocardiographic and policardiographic studies carried out before, during and at the end of treatment. In all cases a return to normal blood pressure values was achieved. No statistically significant changes in these parameters were observed, whereas the blood tests showed a reduction in the uric acid level and a moderate reduction in the potassium level.

Adult↗
PubMed1978

[A case of Churg-Strauss granulomatous angiitis: an autonomous clinical entity or a variant of panarteritis nodosa?].

A fatal case of Churg and Strauss granulomatous angiitis in a 21-yr-old woman is described. Its unusual features included marked personal and familial dysreaction, sudden onset, bronchopulmonitis with distinct eosinophilia and antibiotic- and cortisone-resistant pericarditis, and a terminal picture of generalised septico-pyaemia. The histological findings included necrotising systemic vasculitis with granulomas, some of them extravascular, in various organs. Differential diagnosis and the relation between this form and panarteritis nodosa are discussed.

Adult↗