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Biomedical subjects

R Pla Poblador

Publications and source records attributed to R Pla Poblador.

3 recordsLinked to original sources
PubMedDate not supplied

[Follow-up of the use of metformin among the high risk population].

OBJECTIVE: To perform a follow-up of the use of metformin in order to ensure the appropriate prescription of the drug among the population with the highest risk of adverse reactions. METHOD: A prospective follow-up was conducted of the use of metformin during a four-month period. In the patients recruited for the study, the following data were recorded: age, sex, weight and height, cause of hospitalization, pharmacotherapeutic profile, origin of the prescription (prior to hospitalization or during the hospital stay), glycemia, renal function, side effects and cause of the discontinuation of the treatment, if appropriate. RESULTS: The mean number of patients hospitalized each day during the study period was 352 (standard deviation +/- 36,8), the mean age was 73 years (33-102) and the total number of patients studied was 135, with 46% of males.Since prescription of metformin is contraindicated in patients with creatinine values > 0.132 mMol/L, renal function was monitored. Based on the data of 20 patients, six pharmaceutical interventions were performed in order to recommend the discontinuation of the treatment, which was accepted in 83% of the cases. Side effects and glycemia were also recorded. CONCLUSIONS: During the follow-up period, we did not observe any severe side effects such as associated lactic acidosis, although in some cases metformin was prescribed to patients in which it was not recommended. However, the follow-up of patients is important, since we have observed side effects (diarrhea) that require reduction of the dose of metformin.

Adult↗
PubMedDate not supplied

[Monitoring antidepressant use in acute hospital].

OBJECTIVE: To carry out a prospective study on the current use of antidepressants (ADs) in an acute hospital, in order to determine the prescription sources, therapeutic indications, safety and monitoring of these drugs and their use at patient discharge. METHOD AND RESULTS: To this end the therapeutic drug profiles of non-psychiatric inpatients treated with tri-cyclic antidepressants, selective serotonin re-uptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs) were prospectively reviewed. The following was collected from the patientsâ medical record: reason for admittance, AD indication, prescription source (primary care or in-hospital), modifications of antidepressant treatment during stay, drug-related adverse events (DRAEs), interactions with other drugs, and whether patients were still on antidepressants upon discharge. The mean numer of daily inpatients was 382.6, of which 4.4% received ADs (11-25). Females were 67.5% and males were 32.5%, with a mean age of 67 years (37-92). The total number of patients studied was 126. Prescribed SSRIs represented 73% of cases (92), whereas tricyclic antidepressants represented 27% (34). Prescription originated in primary care for 79.4% of cases (29% tricyclics, 71% SSRIs) and within hospital for 20.6% of cases (tricyclics 11, SSRIs 15), p = 0.02. AD indications were endogenous depression in 72.2%, reactive depression in 7.1%, neuropathic pain in 7.1%, cancer-related pain in 2.4%, and indications not specified in medical records in 11.1%. Treatment was ongoing at patient discharge in 97.5% of cases. CONCLUSIONS: AD prescription source was most commonly primary care. Prescription of ADs for unauthorised indications was seen: management of dementia in the elderly and shyness, support treatment for fibromyalgia, and migraine prophylaxis. In virtually all inpatients on ADs prescriptions were maintained without modification during stay. In the follow-up of patients on ADs, no clinically significant interactions leading to treatment changes were seen.

Acute Disease↗