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Biomedical subjects

R Pompeius

Publications and source records attributed to R Pompeius.

12 recordsLinked to original sources
PubMed1986

Cardiovascular complications of estrogen therapy for nondisseminated prostatic carcinoma. A preliminary report from a randomized multicenter study.

In a prospective multicenter study, 244 men with highly or moderately differentiated prostatic cancer in stage I, II or III (VACURG) were consecutively randomized to three groups of treatment: Group A (77 patients) received polyestradiol phosphate (Estradurin, Leo) 80 mg i.m. every fourth week + ethinyl estradiol (Etivex, Leo) 150 micrograms daily, group B (72 patients) estramustine phosphate (Estracyt, Leo) 280 mg twice daily, and group C (76 patients) no therapy. Only men without current or previous other malignancy and without cardiovascular disease were admitted to the study. After 4 1/2 years 125 of the 244 patients had left the study, 9 because of cancer progression (stage IV, VACURG). The most serious complications were cardiovascular, including ischemic heart disease, cardiac decompensation, cerebral ischemia and venous thromboembolism, which occurred in 24 patients from group A and 9 from group B as compared to only one patient in group C. The subgroup superficial or deep venous thrombosis comprised 11 group A and 2 group B patients. Estrogens (E + e) offered as palliative treatment to patients with non-generalized prostatic carcinoma is burdened with a high incidence of serious cardiovascular complications.

Aged↗
PubMed1981

Blood loss, tissue weight and operating time in transurethral prostatectomy.

The possibility of statistically significant correlation between blood loss during transurethral prostatectomy (TURP) and weight of the resected tissue and/or duration of the operation was explored in 392 patients. All had been operated on by the same surgeon, and in all cases the peroperative blood loss, weight of resected tissue and length of operation were known. A highly significant correlation was found between blood loss and tissue weight, with an overall mean of 15 ml per gram. The severity of bleeding, however, increased with duration of the operation, from 5.2 ml per minute in the smallest glands (less than 10 g) to 20.3 in the largest (greater than 80 g). Speedier surgery is therefore one possibility of reducing blood loss in TURP. In most of the cases with heavy peroperative bleeding, the operating time exceeded one hour. Surgeons should therefore try not to undertake resections that cannot be completed within 60 minutes. If the surgeon is experienced and the estimated prostatic weight less than 30 grams, preoperative crossmatching of blood is not usually necessary.

Hemorrhage↗
PubMed1977

Vein patch grafting for repair of short ureteric strictures.

The generally accepted treatment for short and medium-length strictures of the ureter has been to split the stricture and splint the ureter for a month or more. A new method is here described in which the ureteric stricture is split and the opening is covered with a vein patch-graft. The length of hospital stay is considerably reduced by this operation. Four successfully treated cases with follow-up periods of six months to ten years are presented.

Adult↗
PubMed1975

Effect of trimethoprim-sulfamethoxazole on the renal excretion of creatinine in man.

Treatment with the chemotherapeutic combination of 160 mg. trimethoprim plus 800 mg. sulfamethoxazole twice daily increased the serum creatinine level by an average of 2 mg. per 1. in 21 patients. The effect was clearly reversible. The chemical analysis of creatinine was not affected by the addition of trimethoprim, sulfamethoxazole or their metabolites. In 2 subjects given the drug combination for 12 days renal excretion and 24-hour clearances of creatinine decreased but iothalamate 131I clearance was unchanged. Consequently, the rise in serum creatinine does not indicate any decrease in the glomerular filtration rate. The serum creatinine started to rise within 4 hours after oral administration of a single dose. The rise in serum creatinine could be produced with trimethoprim alone but not with sulfamethoxazole alone. When the plasma creatinine was raised to 100 mg. per l. in healthy subjects (by giving creatinine orally), trimethoprim increased the creatinine levels 10 times as much as at normal plasma levels. The effect was interpreted as a competitive inhibition of the mechanism for tubular secretion of creatinine through the base-secreting pathway.

Creatinine↗