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R Pontier

Publications and source records attributed to R Pontier.

9 recordsLinked to original sources
PubMed1981

Local cerebral glucose utilization in the newborn brain.

Local cerebral glucose utilization (LCGU) was determined in 2- to 8-day-old beagle dogs by the quantitative 14C-deoxyglucose autoradiographic method. In physiologically controlled puppies (BP 66 +/- 3 mm Hg; paO2 71 +/- 2 mm Hg; paCO2 35 mm Hg, pH 7.39 +/- 0.04; hematocrit 39 +/- 2%), the 2-deoxyglucose (2-DG) autoradiographs and quantitative data reveal a characteristic pattern of regional energy metabolic needs in the normal newborn brain: highest glucose consumption values are found in brain stem nuclei (inferior olivary nucleus 19 +/- 4 mumol/100 g/min; vestibular nucleus 26 +/- 5; red nucleus 15 +/- 2) and in selected deep cerebral structures (subthalamic nucleus 18 +/- 4; ventrolateral thalamic nucleus 12 +/- 2, ...) whereas consistently relative lower glucose consumption is found in the cerebral cortex (mean 7 +/- 1). This data is in agreement with local cerebral blood flow studies in the newborn puppy. A characteristic functional anatomy of the newborn dog brain is demonstrated. The value of 0.558 +/- 0.031 for the lumped constant was used in the calculation of LCGU. In puppies previously asphyxiated for 2.5-3.5 min 1-2 days prior to the 2-DG procedure, no significant effect upon regional metabolism was demonstrated.

Animals↗
PubMed1978

[Chronic intracerebral electric stimulation for analgesia in man].

This report concerns the current status of the results of intraencephalic implantations carried out up to the present time in man with the aim of relieving certain forms of chronic pain. It places little emphasis upon the neuro-physiological basis of these implantations, which have been studied at length during previous reports. After presenting the overall results of operations carried out in the world up until September 1967, a critical study is undertaken: 1--In relation to the targets (Postero-Lateral Ventral Nucleus, posterior arm of the internal capsule, para-ventricular thalamic grey matter). 2--In relation to etiologies, both analytically (syndrome) by syndrome as well as in terms of synthesis (excess of pain perception-deafferentation). 3--In terms of various factors, such as: --technical requirements; --side ffects; --duration of "post effect" (residual analgesia after stimulation); --parallel action of drugs. Conclusions are drawn concerning future perspectives of this technique.

Brain↗
PubMed1977

[Glucide intolerance and its pathogenic mechanisms during parenteral feeding].

Hyperglycaemia during parenteral alimentation occurs either as a result of an error in the supplies provided or as a result of diminished carbohydrate tolerance. The circumstances surrounding the development of carbohydrate intolerance are essentially : severe infections, major catabolic states, renal insufficiency, extensive burns, pancreatic problems and diabetes. From a pathogenic standpoint, there are two dominant elements : disturbances in hepatic gluconeogenesis and changes in insulin secretion and in resistance to insulin. The physiopathology is dominated by the risk of hyperosmolarity. Hypoglycaemia occurs most frequently as the result of a manit fest error : too sudded interruption of carbohydrate supplies or two high dosage of exogenous insulin.

Blood Glucose↗
PubMed1975

[Nutrition in the surgical patient with complications].

Parenteral feeding in complicated abdominal surgery has been a definite therapeutic progress. However the authors emphasize the divergent attitudes concerning the amounts of nitrogen which should be supplied as well as the variations in the calories-nitrogen ratio. They propose a practical attitude which must be reevaluated individually.

Abdomen↗