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Biomedical subjects

R Poreba

Publications and source records attributed to R Poreba.

At least 19 recordsLinked to original sources
PubMed2006

Angiogenic and coagulation-fibrinolysis factors in non Hodgkin's lymphoma.

High serum VEGF and bFGF levels are independent prognostic factors of poor prognosis in NHL patients. There is growing evidence that both angiogenesis and haemostatic aberrancies are integral parts of the pathobiology of cancer growth and dissemination. The purpose of the study was: (a) to analyze relations of VEGF and bFGF serum levels, fibrinogen and D-dimer plasma levels with lymphoma Ann Arbor Staging System (AASS) and International Prognostic Index (IPI) and, (b) to evaluate correlations between serum levels of angiogenic cytokines and plasma levels of coagulation-fibrinolysis factors in 52 previously untreated NHL patients included to the study. The control group consisted of 23 healthy volunteers. Serum VEGF, bFGF and plasma D-dimer levels were measured by enzyme-linked immunosorbent assay (ELISA). Plasma levels of fibrinogen were determined on Behring Coagulation System (BCS) equipment. In lymphoma group serum VEGF and bFGF levels were significantly higher than in the control. Differences in concentrations of VEGF, bFGF between II, III and IV stage of disease acc. AASS were not statistically significant. Plasma levels of fibrinogen and D-dimer were elevated in lymphoma patients when compared with the control. Fibrinogen plasma levels were similar in all stages. The D-dimer level was significantly higher in patients with IV stage in comparison to stage II and III. Statistically significant differences of VEGF and bFGF serum levels were observed only between intermediate/high and high risk groups acc. IPI. Fibrinogen plasma levels were significantly higher in high risk group than in low risk group. D-dimer plasma levels were significantly higher in high risk group than in low risk group and low/intermediate group. We observed positive correlation between serum level of VEGF and plasma level of fibrinogen, and between serum level of bFGF and plasma level of fibrinogen. There was also negative correlation between serum level of VEGF and plasma level of D-dimer, and between serum level of bFGF and plasma level of D- dimer. Our study indicates that D-dimer level, but not VEGF, bFGF and fibrinogen correlates with AASS and IPI in NHL patients. Significant correlations between levels of VEGF/bFGF and fibrinogen/D-dimer suggest specific interactions between angiogenic and coagulation-fibrinolysis system.

Female↗
PubMed2001

[Is there any risk interaction between electromagnetic field generated by mobile phones and artificial pacemakers].

Electromagnetic noise is rapidly increasing in the environment. Electromagnetic fields (EMF) originating from a variety of different sources have been shown to interfere with the function of implanted cardiac pacemaker. The authors present the effect of EMF generated by wireless telephones on different types of artificial pacemakers. In addition, instructions on safe use of mobile phones addressed to people with implanted artificial pacemaker are provided.

Arrhythmias, Cardiac↗
PubMed2001

[Urinary trehalase activity as an indicator of renal dysfunction in lead smelters].

Epidemiological and experimental studies have demonstrated that lead and cadmium are responsible for renal dysfunction. Urinary trehalase is known as a good marker of proximal tubular renal brush border destruction in the population environmentally exposed to cadmium. The aim of this study was to determine the impact of occupational exposure to lead on the renal function and urinary trehalase activity. The study was carried out in 68 workers, aged 46 +/- 6 years, employed in a copper foundry. Blood lead, cadmium, copper and manganese concentrations were measured by atomic absorption spectrophotometry. Urinary trehalase activity was determined by the method of Nakano and Itoh. Trehalase activity was increased in copper smelters as compared to controls. There also was a positive linear correlation between blood lead level and urinary trehalase activity (r = 0.44; p < 0.05). Negative correlations between blood lead and copper concentrations (r = -0.30; p < 0.05) and between serum copper and trehalase level (r = 0.68; p < 0.001) were found. The results show that urinary trehalase activity could be a good indicator of the renal brush border dysfunction in copper smelters. This marker could be useful in the early diagnosis of nephrotoxic effect of lead.

Cadmium↗
PubMed2001

Quantitative RT-PCR assay for mRNA of VEGF and histone H4 in the determination of proliferative and angiogenic activity in vulvar pathology.

Proliferative and angiogenic activity of tissue specimens taken from women with various vulvar pathologies were evaluated by determining the number of mRNA VEGF molecules and H4 histone mRNA molecules, by means of the QRT-PCR (TaqMan) technique. Following a cluster analysis the results, where normalised. Euclidean distances were used, all the cases were classified into three groups of pathologies. Group I included low degree vulvar pathologies, group II included high degree vulvar pathologies and group III included vulvar pathologies with high proliferative and angiogenic activity. Significant differences were found in the proliferative and angiogenic activity between groups I and III, and between groups II and III, while no statistically significant differences were found between groups I and II.

Carcinoma in Situ↗
PubMed2001

[Misoprostol and oxytocin in induction of labour in women with prolonged pregnancy--safety and effectiveness comparison].

16 women with prolonged pregnancy and indications to induction of labour were involved into prospective analysis. Sixty of them were given 50 micrograms of Mizoprostol straight into posterior vaginal fornix (only once). In 56 women the labour was induced by intravenous administration of 5 IU Oxytocin. Effectiveness and safety of both preparations used in labour induction were compared. Non-significant higher effectiveness and significant faster induction of uterine contractions by Oxytocin was found. Mizoprostol administration significantly shortens duration of the first labour period. Eventually, time from the medicine administration until the labour in both groups was comparative.

Administration, Intravaginal↗
PubMed2000

[The analysis of 135 water births].

DESIGN: The authors showed the results of the study of the influence of warm tub bath during delivery on 135 women. MATERIALS AND METHODS: In a prospective study 135 women bathed in a warm tub bath during first and second stage of labor after a strictly normal pregnancy, ending with spontaneous delivery at term. A control group consisted of 135 women fulfilling the same criteria, but who did not take the bath during labor. The newborns weight, their condition, perineum injury, time of first and second stage of delivery and number of periteotomies was analyzed. CONCLUSIONS: The observed features were undistinguishing.

Female↗
PubMed2000

[Delivery with husband].

On the basis of the own questionnaire, the research concerning 60 married couples, experiencing family delivery, was made. It was stated that there is strong emotional bound between parents and strong need for experiencing the delivery together.

Adult↗
PubMed2000

[The use of Misoprostol preparation (Cytotec) in induction of labor at prolonged pregnancy].

OBJECTIVES: Safety and effectiveness testing of Misoprostol use at prolonged pregnancies. DESIGN: Prospective, clinical study. MATERIAL AND METHODS: 50 pregnant women with prolonged pregnancy, monocyesis, cephalic longitudinal foetus lie, existing foetal membranes and lack of spontaneous delivery action. Women were given 50 micrograms Misoprostol (Cytotec) to posterior vaginal fornix in case to provoke delivery. Effectiveness of inducing, delivery lasting, way of its finishing and infant condition at birth were controlled. Results were matched with control group of 35 patients with physiological pregnancy, who delivered in spontaneous partus. RESULTS: Effective provocation was observed at 38 pregnant. Natural way delivery was observed at 40 patients. In 10 cases caesarean section was done. Lasting time of birth, way of finishing, infant condition at birth and number of complication do not differ statistically between examined and control group. CONCLUSION: Misoprostol can be effective and save of delivery induction in prolonged pregnancy.

Adult↗
PubMed2000

[Vaginal delivery after previous cesarean: comparison between own method and Weinstein's predictive score].

121 women after previous caesarean section were examined. The amount of successful labours were compared (according to the own diagnostic card) with the foreseeing probability of vaginal labours according to Weinstein's score. 63% pregnant woman was classified to the natural labour on the base of the own diagnostic card, probability of natural labour according to Weinstein's score were more or equal than 67%. There were no agreement between prognostic Weinstein's scale and our own method in the cases of failed attempt of labour followed by caesarean section.

Female↗
PubMed2000

[Ultrasound evaluation of fetal lung maturity in imminent preterm labor cases].

The development of ultrasound examination lets us perform the biophysical assessment of fetus lungs. From 1986, at the Ivth Clinic of Obstetrics and Gynecology in Tychy, examinations of fetus lung were performed with Siemens and Bruel & Kjaer real-time ultrasonographic equipped. The elasticity of fetal lung (DLS--dynamic lung score) was estimated by taking a transversal section through the fetal chest in a plane at fetal in a plane at fetal heart and presented in 3-grade scale: I-grade--lack of elasticity (immaturity of lungs), II-grade--non complete elasticity, III-grade--normal elasticity (maturity of lungs).

Female↗
PubMed2000

[Management of breech delivery in term pregnancy: own diagnostic and prognostic model].

Using own diagnostic and prognostic model, 1157 pregnant women with breech presentation in term were analysed. In 1008 cases (87.1%) they delivered according to prognosis established formerly. Manual support in delivery was required in 748 cases (64.6%). Elective caesarean section was performed in 260 women (22.5%). In 149 cases (12.9%) immediate caesarean section appeared, because of additional reasons, despite normal delivery prognosis.

Breech Presentation↗
PubMed2000

[Serum selectin E level in lead-exposed workers].

Lead is recognised as a potential atherogenic factor. One of the earliest events in the development of atherosclerosis is monicyte attachment to the endothelial surface. This is followed by recruitment of monocytes into the subendothelial space and ingestion of modified LDL by these cells. In turn, modified LDL stimulates endothelial cells to induce expression of proinflammatory adhesion molecules, such as selectins, which further promote monocyte migration. It was observed that atherosclerotic vascular damage is associated with increased level of circulating selectin E. The aim of this study was to determine the impact of the occupational exposure to lead on the serum selectin E level. The study involved 80 patients, including 37 workers of a copper foundry and 43 people not exposed to lead. The subjects were matched in pairs according to sex, age and cholesterol concentration in blood. There were 25 hipercholesterolemic pairs and 9 pairs with normal serum total cholesterol. People exposed to lead had higher (about 7 ng/ml) serum selectin E concentration than those not exposed. There was positive linear correlation between selectin E and triglycerides in the whole group (p < 0.01), and the strongest correlation was observed in the group of subjects not exposed to lead (aged 40-60, r = 0.74). In the context of the described hypertriglyceridemic action induced by lead, these results suggest that lead could potentially act as an atherogenic factor in the early, inflammatory stage of atherosclerosis.

Adult↗
PubMed2000

[Expression of VEGF, KDR, p53, E6 HPV16 and HPV18 in vulvar and cervix cancer].

The aim of the study was a comparison of expression of angiogenesis genes: vascular endothelial growth factor (VEGF), KDR, suppressor gene p53, E6-HPV16 and HPV18, in tissue samples of normal, dystrophic, lymph nodes and malignant cancers of vulva and uterine cervix. The results demonstrate that molecular diagnostics of cancers using gene expression profiling indicates the definitive difference in expression profiles of aforementioned genes in tissues of the same malignancy.

Carcinoma, Squamous Cell↗
PubMed2000

[Analysis of fear structure and intensity at women in prolonged pregnancy].

41 women in prolonged pregnancy were involved into anonymous researches. By the use of survey created in IVth Obstetrics and Gynaecological Department of Silesian Medical School and STAI Spielberger questionnaire and AS Cattell questionnaire and K test MPI Eyseneck Scale--the structure, level of intensity and crystallisation fear was examined. The expectation and wishes of women were known. The general psychological characteristic was done and dominant strategies of coping with difficult situations were isolated. Higher fear levels, mostly of reactive genesis and crystallised mainly on the pregnancy, higher level of ergic tension and suspicion and high level of psychic integration and strong ego were observed.

Adaptation, Psychological↗
PubMed1999

[Polycystic ovary syndrome in adolescent gynecology].

PCO syndrome is a chronic hyperandrogenic disorder beginning in adrenarche. We tried to find a PCO share in general hyperandrogenic population of adolescent girls regarding hormonal and usg parameters. We found LH v FSH ratio > 2:1 as sensitive feature of PCO for most of the patients then other clinical and endocrinological criteria.

Adolescent↗
PubMed1999

[Acantosis nigricans in polycystic ovary syndrome].

Acantosis Nigricans (AN) is a skin disease with rough or velvet areas present on neck or as hyperpigmented and wrinkled skin. AN often forms HAIR-AN syndrome consisted of hyperandrogenizm, insulin resistance and AN. We present AN and PCO syndrome in 13 yrs old girl treated by laparoscopic wedge resection. We concluded that laparoscopic procedure is a diagnostic measure and mode of PCO treatment. Decreased hyperandrogenizm resulted in AN appearance withdrawall.

Acanthosis Nigricans↗
PubMed1999

[The premenstrual syndrome frequency and the intensity of its symptoms in young women and teenagers living in the Upper Silesian Industrial region].

Contemporary home and world medical literatures deal at length with somatic and psychopathologic symptoms connected with changes taking place during the menstrual cycle. The symptoms bring about changes in women's behaviour, life activities and interpersonal relations. The majority of women suffer during the premenstrual period from mood disorder and somatic pains. Nevertheless, the presence of the pains does not diagnose PMS. Over many years PMS has not been clearly defined. Nowadays, making use of precisely-defined criteria, we are able to specify the number of women suffering from the syndrome. Applying the criteria compiled by American Psychiatric Association, we analyse the frequency of PMS occurrence. On the basis of the criteria 180 young women ages 17-25 living in the Upper Silesia Industrial Region have been interviewed. Besides PMS clearly-defined diagnostic criteria the survey included also questions about how the intensity of disorders related to the course of menstrual cycle influences the women's feelings of well-being. The questionnaire scores demonstrate that only few women suffer from PMS defined by American Psychiatric Association, but its symptoms have considerable effects on the women's lives. Simultaneously, many women suffer from numerous pains and disorders which have not been diagnosed as PMS, but which should be examined separately.

Adolescent↗