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Biomedical subjects

R Potter

Publications and source records attributed to R Potter.

At least 37 records · Page 2Linked to original sources
PubMed1986

Sequence and organization of genes encoding the human 27 kDa heat shock protein.

The 27 kDa human heat shock protein (hsp27) is encoded by a gene family of 4 members. Two genomic fragments hybridizing to cDNA encoding hsp27 have been isolated, characterized, and sequenced. One clone is a member of a cluster of three genes linked within a 14-18 kb region of the genome and encodes a transcript interrupted by two intervening sequences. A single open reading frame encodes a polypeptide of 22,300 deduced molecular weight. The 5' flanking region contains two transcription start sites and sequences homologous to the Drosophila consensus heat inducible control element. Induction of both potential transcripts follows heat shock in vivo. Accurate heat inducible transcription occurs at both start sites after injection into Xenopus oocytes. The second genomic clone is a processed pseudogene lacking promoter elements and is unlinked with the other members of the hsp27 gene family. The amino acid sequence of human hsp27 shows striking homology with mammalian alpha crystallin, and contains a region towards the carboxy terminus which shares homology with the small hsp of Drosophila and other organisms.

Amino Acid Sequence↗
PubMed1986

Beer potomania: an unusual cause of symptomatic hyponatremia.

A 43-year-old woman presented to the emergency department with acute agitation, confusion, and tonic seizures. She had a history of drug abuse, most notably beer, which constituted her major dietary intake. The patient's seizures were at first thought to be factitious in association with an acute psychosis; however, her serum sodium concentration was 110 mEq/L and urine sodium was 14 mEq/L. The patient responded to IV hypertonic saline and subsequently recovered completely. Beer potomania, the most likely etiology for this patient's hyponatremia, is a rare disorder in which dietary sodium and protein insufficiency lead to dilutional hyponatremia.

Adult↗
PubMed1984

Which computer?

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Computers↗
PubMed1980

Fluoride distribution in teeth using a silicate model.

The fluoride determinations were done on enamel biopsies taken before and after restoration of extracted teeth with silicate cement. Two sites, one near the restoration and one 3 mm or more away from the restoration, were assayed. No difference was noted in pre- and post-restoration biopsies when teeth were restored with a fluoride-free silicate. Post-restoration biopsies at sites near and away from the restoration were significantly higher in fluoride as compared to pre-restoration biopsies when the teeth were restored with a fluoride-containing silicate.

Dental Cements↗
PubMed1979

Sensitometry of films for nuclear medicine.

A method is described for the determination of characteristic curves for films used in nuclear medicine imaging. Such characteristic curves are presented for a number of commercially available film types and their significance is discussed.

Physical Phenomena↗
PubMed1977

Role of threonine dehydrogenase in Escherichia coli threonine degradation.

Threonine was used as nitrogen source by Escherichia coli K-12 through a pathway beginning with the enzyme threonine dehydrogenase. The 2-amino-3-ketobutyrate formed was converted to glycine, and the glycine was converted to serine, which acted as the actual nitrogen donor. The enzyme formed under anaerobic conditions and known as threonine deaminase (biodegradative) is less widespread than threonine dehydrogenase and may be involved in energy metabolism rather than in threonine degradation per se.

Adenylyl Cyclases↗
PubMed1976

The conversion of leucine to alpha-ketoisocaproic acid and its metabolic consequences for Escherichia coli K12.

The amino acid L-leucine serves as a good auxiliary nitrogen source for Escherichia coli K12, and in so doing is converted to alpha-ketoisocaproic acid which is excreted into the medium. L-Leucine does not serve as sole nitrogen source. Cells incubated with L-leucine as sole nitrogen source do not grow, although they do metabolize leucine, and accumulate ketoisocaproic acid in the medium. Where glycine is the only other nitrogen source, the presence of L-leucine greatly increases the growth rate even at concentrations so low that its contribution as nitrogen donor is unlikely to be important.

Ammonium Sulfate↗