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Biomedical subjects

R Prabhakar

Publications and source records attributed to R Prabhakar.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Persisting alveolitis in miliary tuberculosis despite treatment with short-course chemotherapy.

Bronchoalveolar lavages in two patients with miliary tuberculosis have shown lymphocytic alveolitis. A 6-month regimen with an initial intensive 2-month phase resulted in remarkable clinical and radiographic improvement in both. However, bronchoalveolar lavage following treatment has shown that there was a persistence of lymphocytic alveolitis, though with reduced intensity. The significance of the persisting alveolitis, despite treatment, is not known at present. There is also a suggestion that compartment-alisation of lymphocytes may occur in miliary tuberculosis of the lung.

Adult↗
PubMedDate not supplied

Hydrogen peroxide release by OKIa1 (anti DR--monoclonal antibody) resistant alveolar macrophages in tuberculosis.

Phorbol myristate acetate (PMA) triggered hydrogen peroxide (H2O2) release from alveolar macrophages and corresponding blood monocytes were studied as a whole, in active tuberculosis, inactive tuberculosis (treated), non-tuberculous lung disease patients and normal individuals. Irrespective of the study subjects, the alveolar macrophages produced less H2O2 than the corresponding blood monocytes. The alveolar macrophages that were resistant to OKIa1 (Anti-DR monoclonal antibody and complement treatment) produced an increased level of H2O2 than the control ascites and complement treated alveolar macrophages. Moreover, such increase in H2O2 release was not seen with peripheral blood monocytes; more than 90% monocytes were OKIa1 resistant population. These OKIa1 resistant alveolar macrophages are probably important in their metabolic, microbicidal and the immunological functions.

Antibodies, Monoclonal↗
PubMedDate not supplied

In vitro experiments with Centella asiatica: investigation to elucidate the effect of an indigenously prepared powder of this plant on the acid-fastness and viability of M. tuberculosis.

The herb Centella asiatica (Linn.), found throughout India, is acclaimed to have medicinal properties and has been used in leprosy patients from very early times. It is considered that the active compound of this herb, called asiaticoside, probably acts on the waxy covering of M. leprae. The in vitro effect of an indigenously produced dry powder of Centella asiatica (CA) on the acid-fastness and viability of M. tuberculosis was investigated in the present study. The results indicate that CA may not have any direct action on the acid-fastness or viability of M.tuberculosis H37Rv in vitro. Further studies using purified asiaticoside of the plant or in vivo studies are required.

Microbial Sensitivity Tests↗