PubMed Health⌕ Search

Biomedical subjects

R Prat

Publications and source records attributed to R Prat.

22 records · Page 2Linked to original sources
PubMedDate not supplied

[Cerebral neuroblastomas: diagnosis and treatment].

AIMS: To review the literature on cerebral neuroblastomas (CN), including their anatomopathological filiation, clinical characteristics together with those they display in imaging studies, and the different therapeutic options with their prognosis. METHOD: Cerebral neuroblastomas belong to the group of primitive neuroectodermal tumours (PNET), also known as cerebral meduloblastomas or supratentorial PNET. They originate in the supratentorial compartment and histologically they are in the WHO grade IV. They display unspecific clinical features and in imaging studies they behave like solid masses with a cystic or necrotic component, often with calcifications. Microscopically they are made up of undifferentiated or poorly differentiated neuroepithelial cells. CN express synaptophysin and other neuroendocrine markers, which can only be studied by performing neuronal differentiation analyses. First choice treatment is surgery performed as radically as possible associated with chemotherapy or whole brain radiotherapy. Results vary greatly according to age and the degree to which the lesion has spread. Worse prognoses have been described for children under 2 years old than for those above that age. Survival rate at 3 years of age, including paediatric patients, is 60%. CONCLUSIONS: CN are not very frequent tumours, whose clinical characteristics and those displayed by imaging techniques are unspecific. Treatment must involve radical excision associated with chemotherapy or radiotherapy.

Brain Neoplasms↗
PubMedDate not supplied

[Posterior fossa venous epidural hematoma. Based on 2 cases].

We present two rare cases of posterior fossa epidural hematoma (PFEH) due to occipital fracture and tearing of transverse sinus. One of the patients showed supratentorial and infratentorial extension, which is found in half of the PFEH cases. Both cases experienced clinical worsening within 48 h of the head injury, with control CT showing increase of haematoma volume. Both patients were elected for surgery consisting of suboccipital craniectomy, control of sinus bleeding and sealing of epidural space with dural fixation. Sources of bleeding of PFEH are, by order of frequency, transverse sinus, small dural arteries and sigmoid sinus. PFEH may cause fatal clinical outcome with less volume than supratentorial ones. PFEH have high mortality if not treated. Patients with PFEH and GCS <15 should be admitted to hospital and a control CT should be done if there is deterioration or in the first 24 hours. The treatment of choice is surgery, conservative therapy being an alternative for small PFEH and good clinical evolution.

Adult↗
PubMedDate not supplied

[Space-occupying cerebellar infarcts: surgical or conservative treatment?].

INTRODUCTION: Space-occupying cerebellar infarcts (SOCI) make up a subgroup within the ischemic pathologies of the brain which are generally well tolerated clinically and usually respond well to medical treatment. Yet, in some cases, due to their volume and localisation, they can be accompanied by a progressive deterioration that requires surgical treatment. We report the clinical cases of two patients with SOCI that illustrate both therapeutic alternatives. CASE REPORTS: We describe the case of a 65-year-old male patient with vertiginous syndrome, inability to walk and headache. Computerised axial tomography (CAT) scanning showed a SOCI in the left hemisphere that displaced the 4th ventricle, effaced the cisterns and gave rise to the hydrocephalus. The patient improved clinically with medical treatment and a week later was able to walk unaided. We also describe the case of a 75-year-old female patient with symptoms of deterioration in the level of consciousness. CAT and magnetic resonance scans showed an extensive SOCI in the right hemisphere with displacement of the 4th ventricle, effacement of the perimesencephalic cisterns and triventricular hydrocephalus. A suboccipital craniectomy was performed, along with excision of any necrotic material and duroplasty. At 24 h the patient expressed herself coherently and followed orders. She presented ataxia and dysmetry on the right-hand side following the operation, which were compensated with rehabilitating therapy. CONCLUSIONS: Our clinical case reports illustrate the alternatives available when dealing with patients with cerebellar infarct that show expanding clinical-radiological characteristics. These patients must be carefully controlled because of the risk of clinical deterioration, in which case timely surgical intervention can increase their survival.

Aged↗