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Biomedical subjects

R Quilichini

Publications and source records attributed to R Quilichini.

At least 73 records · Page 4Linked to original sources
PubMed1985

In vivo neutralization of low-molecular weight heparin fraction CY 216 by protamine.

The neutralization in vivo of a low molecular weight heparin by protamine was investigated. Large doses and excessive doses of intravenously administered CY 216 were studied. An intravenous injection of protamine given 10 minutes after the administration of CY 216 did not cause the studied biologic parameters to return to normal levels, but merely attenuated them, whatever the protamine dosage tested. In contrast, the bleeding time and the volume of blood loss resumed normal values that were close to those observed in the controls. This dissociation of actions cannot be explained at present. The ratio of protamine to CY 216 dosage that produced the best results was 1 antiheparin U of protamine to 2 anti-Xa U of CY 216. Nevertheless CY 216 appeared to have a small hemorrhagic potential.

Animals↗
PubMed1985

[Passage of commercial heparin and a low molecular weight fragment of heparin, CY 222, across the placenta of pregnant rabbits].

Because of a further clinical use of low-molecular weight heparin fraction in prevention or treatment of venous thrombo-embolism, it was necessary to establish whether they cross the placenta. The studies were performed in pregnant rabbits. High doses of commercial unfractionated heparin (1 000 and 1 600 anti-Xa units per kg of body-weight) and high doses of a low molecular weight heparin fraction (1 000; 8 000 and 16 000 anti-Xa units per kg of body weight) were injected to animals at the end of gestation (term: 30 days). The placenta crossing was studied by drawing blood samples from the mother and foetus for assays of heparin blood level. There is no detectable levels of heparin in the foetus at any time after injection of commercial heparin at the dose of 1 000 anti-Xa units per kg; meanwhile heparin blood level is very low at the dose of 16 000 anti-Xa units/kg. The low molecular weight heparin fraction do not cross the placenta at the dose of 1 000 anti-Xa units/kg. However for higher doses (8 000 and 16 000 anti-Xa/kg) this heparin fraction gives a foetal heparin blood level upper than the one given by commercial heparin.

Animals↗
PubMed1984

[Diffuse diverticulosis of the small intestine and malabsorption syndrome. Apropos of a case].

A case of acquired jejuno-ileal malabsorption complicated by vitamin B12 malabsorption with macrocytic anemia and posterior column dysfunction is reported. Few such observations have been published in the medical literature. In the light of published studies and case-reports the authors review the pathogenic hypotheses concerning the formation of diverticula, the part played by bacterial infection in the mechanisms of malabsorption and the value of antibiotic therapy in the initial treatment of this condition.

Aged↗
PubMed1983

[Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases].

Two cases of mistaken diagnosis of polycythemia vera leading to useless or dangerous treatments exemplify the old saying "primum non nocere". Absolute polycythemia which lacks both the specific characteristics of polycythemia vera and lacks both the specific characteristics of polycythemia vera and any tumoral etiology (particularly renal) but is accompanied with normal arterial oxygen saturation should suggest the possibility of an anomalous hemoglobin with increased affinity for oxygen. Two alternative mechanisms may be present: anomalous hemoglobins due to the substitution of an amino acid or, as in the two reported cases, a deficit in intraerythrocytic 2,3 diphosphoglyceride. In both cases, polycyhthemia is compensative and does not warrant therapy.

2,3-Diphosphoglycerate↗
PubMed1983

[Horton's disease. Paucisymptomatic forms. Apropos of a series of 37 cases].

Giant cell arteritis (Horton disease) is of growing significance among conditions met in elderly patients. Typical forms are no longer overlooked but occult or incomplete forms, in which one or more characteristic features are lacking, are misleading and may result in a dramatically effective therapeutic decision being deferred. These paucisymptomatic or misleading forms of giant cell arteritis are discussed with reference to 37 personal cases and a review of the medical literature. They have been categorized into ocular, febrile or anemic monosymptomatic forms, extraocular ischemic forms and pseudotumoral forms. Correct diagnosis is worthwhile, in order to avoid the serious consequences of overlooked disease and unnecessary traumatic investigations.

Anemia↗
PubMed1983

Experimental venous thrombosis in rats treated with heparin and a low molecular weight heparin fraction.

An unfractionated mucosal heparin preparation and a low molecular weight heparin fraction were randomly administered to rats subcutaneously. This injection was made on rats with experimentally induced venous thrombosis. At high doses (6.66 mg/kg) of both drugs, thrombus mean weight was reduced in comparison with a control group. At lower doses (2.22 mg/kg) these two drugs inhibited the growth of the thrombus. This inhibition was obtained with a lower dose (0.66 mg/kg) of the low molecular weight heparin fraction than of heparin. The low molecular weight heparin fraction (molecular weight 5,000 daltons) has a high anti-Xa activity (200 units) and a low activity determined by the USP assay (50 units).

Animals↗
PubMed1983

[Partial nodular transformation of the liver with portal hypertension. A new case. Review of the literature].

Based on a case of partial nodular transformation of the liver (PNT) with portal hypertension and splenic microaneurysms in a 24 year old man, the authors review the literature on this subject which only consists of 7 female cases. The authors point out the rarity of this entity which, together with hyperplastic nodular regeneration, is one of the causes of the essential portal hypertension syndrome. They stress the early onset of this disease (mean age of 35 years), on the severity of its clinical course and on the surgical possibilities of porto-caval shunts. The pathogenesis of PNT remains unknown.

Adult↗