Biomedical subjects

R R Chaffee

Publications and source records attributed to R R Chaffee.

8 recordsLinked to original sources

PubMed1979

The possible role of intracellular polyamines in mitochondrial metabolic regulation.

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Adenosine Diphosphate↗

PubMed1978

Polyamine and magnesium effects on mitochondrial respiration in control and heat-acclimated rats.

Studies were made of polyamine and Mg++ effects on rat liver mitochondrial alpha ketoglutarate oxidase (alphaKGO) and succinoxidase (SO). High spermidine levels suppress S3 and S4 of alphaKGO at 0.6-1.17 mM Mg++: some combinations of it and Mg++ increase the respiratory control ratio (RCR). Spermine suppresses S4 of alphaKGO and increases the RCR but suppresses the RCR of SO at high levels. In heat-acclimated (HA) animals in which we have studied only spermine effects on alphaKGO, RCRs of HA rats are greatly increased compared to those of controls.

Acclimatization↗

PubMed1978

The effects of magnesium on state 3 respiration of liver mitochondria from control and cold-acclimated rats and hamsters.

1. Increasing the Mg2+ concentration results in a depression of succinoxidase-linked state 3 respiration of liver mitochondria from both control and cold-acclimated rats and hamsters. 2. It appears that in the cold-acclimated hamster, liver mitochondrial respiration is more sensitive to changes in Mg2+ levels than that of the rat.

Acclimatization↗

PubMed1977